Immunotherapy response and resistance in patients with advanced uveal melanoma: a retrospective cohort study
Sign Up to like & getrecommendations! Published in 2024 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-024-01497-8
Abstract: Metastatic uveal melanoma (mUM) is associated with poor prognosis. Ipilimumab/nivolumab has shown antitumor efficacy in phase II studies. Tebentafusp resulted in longer overall survival (OS) compared to investigator`s choice in a phase III study. We… read more here.
Keywords: uveal melanoma; response resistance; response; ipilimumab nivolumab ... See more keywords
M55 Pharmacogenetic Study of Antipsychotic Response To Treatment In Mexican Patients with Schizophrenia: Analysis of Response And Resistance
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2016.09.446
Abstract: Background The efficacy of antipsychotics treatment in schizophrenia patients has long been established; however, clinical response to these drugs is not the same in all patients. Genetic variability has been proposed as the main reason… read more here.
Keywords: response; analysis; treatment; response treatment ... See more keywords
A Quasi-Experimental Evaluation of the Effects of Police Body-Worn Cameras (BWCs) on Response-to-Resistance in a Large Metropolitan Police Department
Sign Up to like & getrecommendations! Published in 2017 at "Deviant Behavior"
DOI: 10.1080/01639625.2016.1248711
Abstract: ABSTRACT The current study provides a statistically rigorous program evaluation of the impact of police body-worn cameras (BWCs) on police response-to-resistance (e.g., use of force). Results indicate that BWC officers’ mean frequency of response-to-resistance decreased… read more here.
Keywords: worn cameras; response; body worn; response resistance ... See more keywords
Clozapine Optimization: A Delphi Consensus Guideline From the Treatment Response and Resistance in Psychosis Working Group.
Sign Up to like & getrecommendations! Published in 2023 at "Schizophrenia bulletin"
DOI: 10.1093/schbul/sbad030
Abstract: BACKGROUND AND HYPOTHESIS There is limited evidence to guide the approaches to clozapine treatment. Accordingly, an international initiative was undertaken with the aim of developing consensus recommendations for the optimization of clozapine monotherapy. STUDY DESIGN… read more here.
Keywords: consensus; response resistance; delphi; clozapine ... See more keywords
Effects of dietary soy isoflavones on growth, antioxidant status, immune response and resistance of juvenile grass carp ( Ctenopharyngodon idella ) to Aeromonas hydrophila challenge
Sign Up to like & getrecommendations! Published in 2020 at "Aquaculture Research"
DOI: 10.1111/are.14590
Abstract: The current study was conducted to evaluate the effect of dietary soy isoflavones (SI) on growth performance, antioxidant status, immune response and resistance to Aeromonas hydrophila in juvenile grass carp (Ctenopharyngodon idella). Six diets were… read more here.
Keywords: response resistance; dietary soy; group; immune response ... See more keywords
Photoacoustic Tomography Detects Response and Resistance to Bevacizumab in Breast Cancer Mouse Models.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-0626
Abstract: Angiogenesis is an established prognostic factor in advanced breast cancer, yet response to antiangiogenic therapies in this disease remains highly variable. Noninvasive imaging biomarkers could help identify patients that will benefit from antiangiogenic therapy and… read more here.
Keywords: response resistance; response; cancer; breast cancer ... See more keywords
Abstract 2278: Dissecting immuno-genomic pathways of response and resistance to immunotherapy in metastatic urothelial carcinoma in a real-world cohort
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2278
Abstract: Background: While Immune Checkpoint Inhibitors (ICI) are widely used for the treatment (tx) of patients (pts) with metastatic urothelial carcinoma (mUC), response rates are only around 20%. There is an unmet need to develop biomarkers… read more here.
Keywords: metastatic urothelial; response resistance; cohort; urothelial carcinoma ... See more keywords
Cell-free circulating chromatin profiling for epigenomic characterization of mechanisms of response and resistance to sacituzumab govitecan in breast cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.1081
Abstract: 1081 Background: The efficacy of sacituzumab govitecan (SG), a TROP2-directed antibody-drug conjugate (ADC), in hormone receptor-positive/HER2-negative (HR+/HER2-) metastatic breast cancer (mBC) has been demonstrated, yet biomarkers predicting response and resistance remain an unmet clinical need.… read more here.
Keywords: breast cancer; resistance; response resistance;
Novel Molecular Determinants of Response or Resistance to Immune Checkpoint Inhibitor Therapies in Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.798474
Abstract: Background Immune checkpoint inhibitor (ICI) therapy dramatically prolongs melanoma survival. Currently, the identified ICI markers are sometimes ineffective. The objective of this study was to identify novel determinants of ICI efficacy. Methods We comprehensively curated… read more here.
Keywords: response resistance; resistance; checkpoint inhibitor; immune checkpoint ... See more keywords