Leukocyte Transcriptional Response in Sepsis.
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DOI: 10.1097/shk.0000000000001258
Abstract: BACKGROUND The complex host response to sepsis is incompletely understood. The aim of this investigation is to use leukocyte RNA sequencing to characterize biological functions, cellular pathways, and key regulatory molecules driving sepsis pathophysiology. METHODS… read more here.
Keywords: sepsis; regulatory molecules; response; cellular pathways ... See more keywords
Unique transcriptomic response to sepsis is observed among patients of different age groups
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DOI: 10.1371/journal.pone.0184159
Abstract: Sepsis is a major cause of morbidity and mortality, especially at the extremes of age. To understand the human age-specific transcriptomic response to sepsis, a multi-cohort, pooled analysis was conducted on adults, children, infants, and… read more here.
Keywords: sepsis; transcriptomic response; age; age groups ... See more keywords
Early Host Interactions That Drive the Dysregulated Response in Sepsis
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DOI: 10.3389/fimmu.2019.01748
Abstract: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. While many individual cells and systems in the body are involved in driving the excessive and sometimes sustained host response,… read more here.
Keywords: sepsis; response; host response; response sepsis ... See more keywords
RIPK1 in the inflammatory response and sepsis: Recent advances, drug discovery and beyond
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1114103
Abstract: Cytokine storms are an important mechanism of sepsis. TNF-α is an important cytokine. As a regulator of TNF superfamily receptors, RIPK1 not only serves as the basis of the scaffold structure in complex I to… read more here.
Keywords: sepsis; inflammatory response; response sepsis; ripk1 inflammatory ... See more keywords
Re-Evaluating Biologic Pharmacotherapies That Target the Host Response during Sepsis
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DOI: 10.3390/ijms20236049
Abstract: Multiple organ dysfunction syndrome (MODS) caused by the systemic inflammatory response during sepsis is responsible for millions of deaths worldwide each year, and despite broad consensus concerning its pathophysiology, no specific or effective therapies exist.… read more here.
Keywords: sepsis; evaluating biologic; response; host response ... See more keywords
Transcriptional Response in a Sepsis Mouse Model Reflects Transcriptional Response in Sepsis Patients
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DOI: 10.3390/ijms23020821
Abstract: Mortality due to sepsis remains unacceptably high, especially for septic shock patients. Murine models have been used to better understand pathophysiology mechanisms. However, the mouse model is still under debate. Herein we investigated the transcriptional… read more here.
Keywords: response; sepsis; cells stimulated; transcriptional response ... See more keywords