Vaccination targeting human HER3 alters the phenotype of infiltrating T cells and responses to immune checkpoint inhibition
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1315495
Abstract: ABSTRACT Expression of human epidermal growth factor family member 3 (HER3), a critical heterodimerization partner with EGFR and HER2, promotes more aggressive biology in breast and other epithelial malignancies. As such, inhibiting HER3 could have… read more here.
Keywords: immune checkpoint; responses immune; checkpoint inhibition; her3 ... See more keywords
HIV reservoir: antiviral immune responses and immune interventions for curing HIV infection
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000002479
Abstract: Abstract Antiretroviral therapy against human immunodeficiency virus (HIV) is effective in controlling viral replication but cannot completely eliminate HIV due to the persistence of the HIV reservoir. Innate and adaptive immune responses have been proposed… read more here.
Keywords: hiv; responses immune; immune responses; hiv reservoir ... See more keywords
The role of microglia in 67NR mammary tumor-induced suppression of brain responses to immune challenges in female mice.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15830
Abstract: It is poorly understood how solid peripheral tumors affect brain neuroimmune responses despite the various brain-mediated side effects and higher rates of infection reported in cancer patients. We hypothesized that chronic low-grade peripheral tumor-induced inflammation… read more here.
Keywords: responses immune; mammary tumor; tumor induced; brain ... See more keywords
Value of a Signature of Immune-Related Genes in Predicting the Prognosis of Melanoma and Its Responses to Immune Checkpoint Blocker Therapies
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DOI: 10.1155/2022/9633416
Abstract: Melanoma is becoming increasingly common worldwide, with high rates of transformation into malignancy compared to other skin lesions. The prognosis of patients with melanoma at an advanced stage is highly unsatisfying despite the development of… read more here.
Keywords: checkpoint blocker; responses immune; immune checkpoint; blocker therapies ... See more keywords