A single subcutaneous or intranasal immunization with adenovirus‐based SARS‐CoV‐2 vaccine induces robust humoral and cellular immune responses in mice
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202149167
Abstract: Optimal vaccines are needed for sustained suppression of SARS‐CoV‐2 and other novel coronaviruses. Here, we developed a recombinant type 5 adenovirus vector encoding the gene for the SARS‐CoV‐2 S1 subunit antigen (Ad5.SARS‐CoV‐2‐S1) for COVID‐19 immunization… read more here.
Keywords: responses mice; immunization; cov vaccine; immune responses ... See more keywords
A PEG-lipid-free COVID-19 mRNA vaccine triggers robust immune responses in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Materials horizons"
DOI: 10.1039/d2mh01260j
Abstract: COVID-19 mRNA vaccines represent a completely new category of vaccines and play a crucial role in controlling the COVID-19 pandemic. In this study, we have developed a PEG-lipid-free two-component mRNA vaccine (PFTCmvac) by formulating mRNA… read more here.
Keywords: lipid free; responses mice; peg lipid; covid mrna ... See more keywords
Per1 mutation enhances masking responses in mice
Sign Up to like & getrecommendations! Published in 2022 at "Chronobiology International"
DOI: 10.1080/07420528.2022.2126321
Abstract: ABSTRACT Light can restrict the activity of an animal to a diurnal or nocturnal niche by synchronizing its endogenous clock (entrainment) which controls the sleep wake cycle. Light can also directly change an animal’s activity… read more here.
Keywords: masking responses; responses mice; per1 mutation; per1 per2 ... See more keywords
Interleukin-1β signaling in fenestrated capillaries is sufficient to trigger sickness responses in mice
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DOI: 10.1186/s12974-017-0990-7
Abstract: BackgroundThe physiological and behavioral symptoms of sickness, including fever, anorexia, behavioral depression, and weight loss can be both beneficial and detrimental. These sickness responses are triggered by pro-inflammatory cytokines acting on cells within the brain.… read more here.
Keywords: cells within; responses mice; sickness responses; fenestrated capillaries ... See more keywords
Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice
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DOI: 10.1371/journal.pone.0239246
Abstract: Alcohol use disorder (AUD) is a chronic relapsing disorder characterized by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. AUD is associated with a variety of physiological… read more here.
Keywords: responses mice; ifn responses; alcohol dependence; promotes systemic ... See more keywords