Tenuigenin inhibits LPS‐induced inflammatory responses in microglia via activating the Nrf2‐mediated HO‐1 signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.05.004
Abstract: &NA; Tenuigenin (TGN), a major active component of polygala tenuifolia root, has been reported to have anti‐inflammatory effect. In this study, we investigated the anti‐neuroinflammatory effects of TGN on LPS‐induced inflammation both in vitro and… read more here.
Keywords: inflammatory responses; via activating; responses microglia; lps induced ... See more keywords
m6A Reader Igf2bp1 Regulates the Inflammatory Responses of Microglia by Stabilizing Gbp11 and Cp mRNAs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.872252
Abstract: Microglia are brain resident cells that function as brain phagocytic macrophages. The inflammatory responses of microglia induced by pathologic insults are key regulators in the progression of various neurological disorders. Currently, little is known about… read more here.
Keywords: inflammatory responses; m6a methylation; responses microglia; reader igf2bp1 ... See more keywords
Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis
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DOI: 10.3389/fncel.2020.00269
Abstract: Microglia play an essential role in maintaining central nervous system (CNS) homeostasis, as well as responding to injury and disease. Most neurological disorders feature microglial activation, a process whereby microglia undergo profound morphological and transcriptional… read more here.
Keywords: responses microglia; microglia animal; dynamic responses; multiple sclerosis ... See more keywords
Human β-Defensin 3 Inhibits Porphyromonas Gingivalis Lipopolysaccharide-Induced Oxidative and Inflammatory Responses of Microglia by Suppression of Cathepsins B and L
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232315099
Abstract: Recently, the effects of antibacterial peptides are suggested to have therapeutic potential in Alzheimer’s disease. Furthermore, systemic treatment of Porphyromonas gingivalis (Pg) lipopolysaccharide (LPS) induced Alzheimer’s disease-like neuropathological changes in middle-aged mice. Then, we examined… read more here.
Keywords: inflammatory responses; responses microglia; lps induced; oxidative inflammatory ... See more keywords