Pharmacological perturbation reveals deficits in D2 receptor responses in Thap1 null mice.
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DOI: 10.1002/acn3.51481
Abstract: The primary dystonia DYT6 is caused by mutations in the transcription factor Thanatos-associated protein 1 (THAP1). To understand THAP1's functions, we generated mice lacking THAP1 in the nervous system. THAP1 loss causes locomotor deficits associated… read more here.
Keywords: receptor responses; deficits receptor; reveals deficits; pharmacological perturbation ... See more keywords