An Engineered Nanosugar Enables Rapid and Sustained Glucose‐Responsive Insulin Delivery in Diabetic Mice
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202210392
Abstract: Glucose‐responsive insulin‐delivery platforms that are sensitive to dynamic glucose concentration fluctuations and provide both rapid and prolonged insulin release have great potential to control hyperglycemia and avoid hypoglycemia diabetes. Here, biodegradable and charge‐switchable phytoglycogen nanoparticles… read more here.
Keywords: insulin release; glucose responsive; insulin delivery; responsive insulin ... See more keywords
Stimuli-Responsive Insulin Delivery Devices.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical research"
DOI: 10.1007/s11095-020-02918-5
Abstract: The development of new diabetes treatment strategies has garnered much interest given that conventional management therapies for type 1 diabetes fail to provide optimal glycemic control while creating a high burden of self-care to patients.… read more here.
Keywords: responsive insulin; delivery; delivery devices; stimuli responsive ... See more keywords
Microgel encapsulated nanoparticles for glucose-responsive insulin delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120458
Abstract: An insulin delivery system that self-regulates blood glucose levels has the potential to limit hypoglycemic events and improve glycemic control. Glucose-responsive insulin delivery systems have been developed by coupling glucose oxidase with a stimuli-responsive biomaterial.… read more here.
Keywords: insulin; responsive insulin; glucose responsive; insulin delivery ... See more keywords
Erythrocyte-Membrane-Enveloped Biomineralized Metal-Organic Framework Nanoparticles Enable Intravenous Glucose-Responsive Insulin Delivery.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c01943
Abstract: A "closed-loop" insulin delivery system that can mimic the dynamic and glucose-responsive insulin secretion as islet β-cells is desirable for the therapy of type 1 and advanced type 2 diabetes mellitus (T1DM and T2DM). Herein,… read more here.
Keywords: insulin; responsive insulin; glucose responsive; insulin delivery ... See more keywords
Strategy for peptide quantification using LC-MS in regulated bioanalysis: case study with a glucose-responsive insulin.
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DOI: 10.4155/bio-2018-0089
Abstract: AIM Advances in technology have led to a shift for peptide quantification from traditional ligand-binding assays to LC-MS/MS-based analysis, which presents challenges, in other assay sensitivity, specificity and ruggedness, in addition to lacking of regulatory… read more here.
Keywords: responsive insulin; glucose responsive; strategy; peptide quantification ... See more keywords