Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels
Sign Up to like & getrecommendations! Published in 2017 at "Febs Letters"
DOI: 10.1002/1873-3468.12651
Abstract: Although neuroglobin confers neuroprotection against Alzheimer's disease (AD) pathology, its expression becomes downregulated in late‐stage AD. Here, we provide evidence that indicates that this decrease is associated with the AD‐linked angiopathy. While wild‐type mice of… read more here.
Keywords: rest nrsf; app23 mice; pathology; expression ... See more keywords
The role of REST/NRSF, TrkB and BDNF in neurobiological mechanisms of different susceptibility to seizure in a PTZ model of epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.03.007
Abstract: Global transcriptional disturbances are believed to play a major role in the course of epilepsy. Due to the high complexity, the neurobiological mechanisms underlying different susceptibility to seizure and epilepsy are not well known. A… read more here.
Keywords: rest nrsf; role; different susceptibility; bdnf ... See more keywords
Repressor element 1 silencing transcription factor /neuron-restrictive silencing factor (REST/NRSF) in social stress and depression
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.110053
Abstract: Extreme stress is closely linked with symptoms of depression. Chronic social stress can cause structural and functional changes in the brain. These changes are associated with dysfunction of neuroprotective signalling that is necessary for cell… read more here.
Keywords: social stress; depression; rest nrsf; stress ... See more keywords
A REST Paradox: Does it Control or Enhance Neural Activity?
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DOI: 10.1177/15357597221081582
Abstract: The repressor-element 1-silencing transcription/neuron-restrictive silencer factor (REST/NRSF) controls hundreds of neuronspecific genes. We showed that REST/NRSF downregulates glutamatergic transmission in response to hyperactivity, thus contributing to neuronal homeostasis. However, whether GABAergic transmission is also implicated… read more here.
Keywords: inhibition; rest; paradox control; rest paradox ... See more keywords
Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF
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DOI: 10.15252/embr.202051524
Abstract: Advanced paternal age can have deleterious effects on various traits in the next generation. Here, we establish a paternal‐aging model in mice to understand the molecular mechanisms of transgenerational epigenetics. Whole‐genome target DNA methylome analyses… read more here.
Keywords: affects offspring; age affects; rest nrsf; paternal age ... See more keywords