Ultrasmall Nanoparticles Mitigate Tau Hyperphosphorylation to Restore Synaptic Integrity and Boost Cognitive Function in Alzheimer's Disease
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DOI: 10.1002/adhm.202500941
Abstract: Tau hyperphosphorylation represents a critical pathological hallmark of Alzheimer's disease (AD), a prevalent neurodegenerative disorder characterized by progressive cognitive decline. The ubiquitin‐specific proteases 14 (USP14) impairs proteasomal function and accelerates hyperphosphorylated Tau accumulation, making it… read more here.
Keywords: alzheimer disease; synaptic integrity; tau hyperphosphorylation; hyperphosphorylation ... See more keywords
Microdosing Psychedelics to Restore Synaptic Density in Schizophrenia
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DOI: 10.3390/ijms26188949
Abstract: Schizophrenia is a highly polygenic disease, and several genetic variants associated with the disease converge on altered synaptic homeostasis. In particular, the gene encoding complement component 4 (C4) showed the strongest association with schizophrenia, and… read more here.
Keywords: schizophrenia; synaptic density; microdosing psychedelics; psychedelics restore ... See more keywords