Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells.
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DOI: 10.1016/j.celrep.2018.12.078
Abstract: The thymoproteasome subunit β5t is specifically expressed in cortical thymic epithelial cells (TECs) and generates unique peptides to support positive selection. In this study, using a mouse model ubiquitously expressing β5t, we showed that aberrant… read more here.
Keywords: homeostasis; cd8; cd8 cells; selection ... See more keywords