Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design.
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DOI: 10.1021/acs.jmedchem.9b00751
Abstract: Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disease whose pathogenesis cannot be defined by one single element but consist of various factors; thus, there is a call for alternative approaches to tackle the multifaceted… read more here.
Keywords: glutaminyl cyclase; discovery conformationally; conformationally restricted; restricted human ... See more keywords