Restricted Mean Survival Time Analysis to Estimate SGLT2i–Associated Heterogeneous Treatment Effects on Primary and Secondary Prevention of Cardiorenal Outcomes in Patients With Type 2 Diabetes in Taiwan
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.46928
Abstract: Key Points Question Is restricted mean survival time (RMST) analysis feasible to translate comparative cardiovascular and kidney outcomes of sodium-glucose cotransporter-2 inhibitor (SGLT2i) vs dipeptidyl peptidase-4 inhibitor (DPP4i) therapy in routine clinical settings? Findings In… read more here.
Keywords: cardiorenal outcomes; restricted mean; analysis; mean survival ... See more keywords
A nonparametric simultaneous confidence band for biomarker effect on the restricted mean survival time
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9618
Abstract: Study of prognostic and predictive biomarkers plays an important role in the design and analysis of clinical trials. The Cox proportional hazards model is often used to study the biomarker main effect and the treatment‐biomarker… read more here.
Keywords: effect; biomarker; restricted mean; mean survival ... See more keywords
The Restricted Mean Survival Time as a Tool for Ranking Comparative Outcomes in a Narrative Review that Evaluates a Network of Randomized Trials: An Example Based on PCSK9 Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Cardiovascular Drugs"
DOI: 10.1007/s40256-020-00444-8
Abstract: Introduction On the basis of two randomized trials, evolocumab and alirocumab have been approved in patients with cardiovascular disease. The evidence on these two agents has been studied through different methods of analysis that span… read more here.
Keywords: survival time; network; narrative review; restricted mean ... See more keywords
Restricted Mean Survival Time for Analysis and Interpretation of Clinical Trials for Heart Failure Devices
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2020.09.189
Abstract: Introduction Treatment effects in heart failure (HF) clinical trials are typically summarized as hazard ratios (HR). However, a HR alone without a reference value of the hazard from the control arm is difficult to interpret… read more here.
Keywords: time; treatment; clinical trials; restricted mean ... See more keywords
Restricted Mean Survival Times to Improve Communication of Evidence from Cancer Randomized Trials and Observational Studies.
Sign Up to like & getrecommendations! Published in 2019 at "European urology"
DOI: 10.1016/j.eururo.2019.04.002
Abstract: Hazard ratios (HRs) are frequently misinterpreted. We describe an easily estimated complementary measure, the difference in restricted mean survival time (RMST), that requires fewer assumptions than the HR and is more readily interpretable. Reporting RMST-based… read more here.
Keywords: communication evidence; improve communication; restricted mean; survival times ... See more keywords
Estimation on conditional restricted mean survival time with counting process
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2019.1657129
Abstract: ABSTRACT In traditional survival analyses, hazard ratio (HR) is commonly used to evaluate treatment effects. However, HR may not be easy to interpret. Restricted mean survival time is a viable alternative to HR, particularly when… read more here.
Keywords: conditional restricted; survival time; counting process; time ... See more keywords
Dissecting the restricted mean time in favor of treatment.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2023.2210658
Abstract: The restricted mean time in favor (RMT-IF) summarizes the treatment effect on a hierarchical composite endpoint with mortality at the top. Its crude decomposition into "stage-wise effects," i.e., the net average time gained by the… read more here.
Keywords: time favor; time; restricted mean; treatment ... See more keywords
Deep neural networks for predicting restricted mean survival times
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa1082
Abstract: AVAILABILITY AND IMPLEMENTATION Restricted mean survival time (RMST) is a useful summary measurement of the time-to-event data, and it has attracted great attention for its straightforward clinical interpretation. In this article, I propose a deep… read more here.
Keywords: network; deep neural; network model; restricted mean ... See more keywords
On estimating optimal regime for treatment initiation time based on restricted mean residual lifetime.
Sign Up to like & getrecommendations! Published in 2021 at "Biometrics"
DOI: 10.1111/biom.13530
Abstract: When to initiate treatment on patients is an important problem in many medical studies such as AIDS and cancer. In this article, we formulate the treatment initiation time problem for time-to-event data and propose an… read more here.
Keywords: initiation; treatment; restricted mean; treatment initiation ... See more keywords
Tisagenlecleucel in Non-Hodgkin Lymphoma: The Restricted Mean Survival Time as a Tool for Estimating Progression-Free Life Expectancy Better than the Median
Sign Up to like & getrecommendations! Published in 2020 at "Acta Haematologica"
DOI: 10.1159/000505891
Abstract: Dear Editor, Although the restricted mean survival time (RMST) is considered a new methodological tool for interpreting survival curves, its development dates back to more than 15 years ago. In comparison with the median, the… read more here.
Keywords: rmst; time; restricted mean; progression free ... See more keywords
Generalized fiducial inference for the restricted mean survival time.
Sign Up to like & getrecommendations! Published in 2023 at "Statistical methods in medical research"
DOI: 10.1177/09622802231163333
Abstract: The standard modeling approach for time-to-event outcomes subject to censoring is based on the hazard function, with hazard ratios capturing the effect of exposures on the risk of outcome. The restricted mean survival time, defined… read more here.
Keywords: time; generalized fiducial; restricted mean; mean survival ... See more keywords