Discovery of Axelopran (TD-1211): A Peripherally Restricted μ-Opioid Receptor Antagonist.
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DOI: 10.1021/acsmedchemlett.9b00406
Abstract: The effects of opioids in the central nervous system (CNS) provide significant benefit in the treatment of pain but can also lead to physical dependence and addiction, which has contributed to a growing opioid epidemic… read more here.
Keywords: receptor antagonist; peripherally restricted; opioid receptor; restricted opioid ... See more keywords