Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.
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DOI: 10.1016/j.celrep.2019.08.068
Abstract: Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor immunosurveillance. Here, we report that melanoma patients with high expression of glycolysis-related genes show a worse progression free survival upon anti-PD1… read more here.
Keywords: checkpoint therapy; glycolysis preserves; glycolysis; effector functions ... See more keywords