PR-DUB safeguards Polycomb repression through H2AK119ub1 restriction.
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DOI: 10.1111/cpr.13457
Abstract: Polycomb group (PcG) proteins are critical chromatin regulators for cell fate control. The mono-ubiquitylation on histone H2AK119 (H2AK119ub1) is one of the well-recognized mechanisms for Polycomb repressive complex 1 (PRC1)-mediated transcription repression. Unexpectedly, the specific… read more here.
Keywords: h2ak119ub1 restriction; restriction dub; dub; repression ... See more keywords