Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.11.004
Abstract: Aim: In the present study, attempts have been made to evaluate the potential role of fisetin, a caloric restriction mimetic (CRM), for neuroprotection in D‐galactose (D‐gal) induced accelerated and natural aging models of rat. Main… read more here.
Keywords: fisetin caloric; aging induced; restriction mimetic; caloric restriction ... See more keywords
Fisetin, a potential caloric restriction mimetic, modulates ionic homeostasis in senescence induced and naturally aged rats.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2019.1662452
Abstract: Context: Fisetin as a caloric restriction mimetic (CRM) exerts numerous beneficial effects on different aging model systems. The effect of fisetin on erythrocyte membrane functions against induced aging is not very clear. Objectives: The potential… read more here.
Keywords: aged rats; senescence induced; caloric restriction; ionic homeostasis ... See more keywords
3-Bromopyruvate elevates ROS and induces hormesis to exert a caloric restriction mimetic effect in young and old rats.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2020.1828485
Abstract: CONTEXT 3-Bromopyruvate (3-BP) is a glycolytic inhibitor and a putative caloric restriction mimetic. OBJECTIVE We have examined the effect of low-dose administration of 3-BP to rats and assess the CRM effect by measuring an array… read more here.
Keywords: old rats; caloric restriction; effect; restriction mimetic ... See more keywords
Chitosan displays a potent caloric restriction mimetic effect in senescent rats.
Sign Up to like & getrecommendations! Published in 2021 at "Rejuvenation research"
DOI: 10.1089/rej.2021.0010
Abstract: Chitosan is a polysaccharide made up of β1,4-linked D-glucosamine (GlcN) and N-acetyl-GlcN. In this study, we evaluated the possible caloric restriction mimetic effect of dietary chitosan on systemic redox status, inflammatory biomarkers and lipid profile… read more here.
Keywords: restriction mimetic; mimetic effect; caloric restriction; senescent rats ... See more keywords
Caloric Restriction Mimetic 2-Deoxyglucose Reduces Inflammatory Signaling in Human Astrocytes: Implications for Therapeutic Strategies Targeting Neurodegenerative Diseases
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DOI: 10.3390/brainsci12030308
Abstract: Therapeutic interventions are greatly needed for age-related neurodegenerative diseases. Astrocytes regulate many aspects of neuronal function including bioenergetics and synaptic transmission. Reactive astrocytes are implicated in neurodegenerative diseases due to their pro-inflammatory phenotype close association… read more here.
Keywords: caloric restriction; human astrocytes; therapeutic strategies; restriction mimetic ... See more keywords