A FOXO-dependent replication checkpoint restricts proliferation of damaged cells.
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DOI: 10.1016/j.celrep.2020.108675
Abstract: DNA replication is challenged by numerous exogenous and endogenous factors that can interfere with the progression of replication forks. Substantial accumulation of single-stranded DNA during DNA replication activates the DNA replication stress checkpoint response that… read more here.
Keywords: replication; restricts proliferation; replication stress; checkpoint ... See more keywords