Immunochemical and LC-MS/MS Detection of Protein Adduction Resulting from Metabolic Activation of Columbin In Vitro and In Vivo.
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DOI: 10.1021/acs.chemrestox.3c00006
Abstract: Columbin (CLB) is a diterpenoid furanolactone compound occurring in some herbal medicines. Administration of CLB has been reported to induce liver injury. The reported CLB hepatotoxicity is suggested to require metabolism to a cis-enedial intermediate.… read more here.
Keywords: resulting metabolic; metabolic activation; adduction resulting; adduction ... See more keywords