Glycosylation of Erwinase results in active protein less recognized by antibodies
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DOI: 10.1016/j.bej.2020.107750
Abstract: Abstract L-asparaginase (L-ASNase) is an important bacterial enzyme used as a biopharmaceutical to treat acute lymphoblastic leukemia (ALL). Side effects of L–ASNase therapy have been counteracted by polyethylene glycol (PEG)-modification of L-ASNase; however, immunogenicity of… read more here.
Keywords: erwinase results; glycosylation; results active; asnase ... See more keywords