PNPase knockout results in mtDNA loss and an altered metabolic gene expression program
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DOI: 10.1371/journal.pone.0200925
Abstract: Polynucleotide phosphorylase (PNPase) is an essential mitochondria-localized exoribonuclease implicated in multiple biological processes and human disorders. To reveal role(s) for PNPase in mitochondria, we established PNPase knockout (PKO) systems by first shifting culture conditions to… read more here.
Keywords: pnpase; results mtdna; gene expression; pko ... See more keywords