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Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2438_136
Abstract: treat (ITT) is 71% and 57%, respectively (Figure 1). Conclusion: Ibrutinib dosed at 840 mg daily in combination with R‐ICE is well tolerated and enables HPC collection. Encouragingly, 89% of patients achieved a response; including…
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Keywords:
combination;
study tirabrutinib;
results phase;
preliminary results ... See more keywords
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Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2439_186
Abstract: and anemia (12%). The overall response rate (ORR) was 71% (12/17 pts) and median progression‐free survival (PFS) was not estimable across all cohorts; ORR in each subtype was 80% (4/5 pts) in DLBCL with 1…
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Keywords:
cll;
clinical results;
analysis clinical;
results phase ... See more keywords
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Published in 2018 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2018.08.1250
Abstract: since we will be able to compare our results with the once published previously. Method: We have reviewed 129 patients with NSCLC, advanced or recurrent stages, treated with nivolCutumab either in second and subsequent lines…
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Keywords:
response;
results phase;
treatment;
interim results ... See more keywords
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Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab076.418
Abstract: IL-10 is a pleiotropic anti-inflammatory cytokine that restores mucosal homeostasis. Genetic deficiencies in IL-10 cause intestinal inflammation in mice and are associated with early onset IBD in humans. In mice, this can be reversed by…
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Keywords:
gut selective;
amt 101;
fusion;
patients active ... See more keywords
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Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.014
Abstract: Genetically engineered, conditionally replicating herpes simplex viruses type 1 (HSV-1) are promising therapeutic agents for cancer. We have developed a triple-mutated, third-generation oncolytic HSV-1, G47∆, that exhibits enhanced replication capability in a variety of cancer,…
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Keywords:
clinical trial;
trial;
results phase;
drug ... See more keywords
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Published in 2017 at "Journal of the American Geriatrics Society"
DOI: 10.1111/jgs.14927
Abstract: To assess the effects of bimagrumab on skeletal muscle mass and function in older adults with sarcopenia and mobility limitations.
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Keywords:
randomized controlled;
results phase;
bimagrumab results;
phase randomized ... See more keywords
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Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.7027
Abstract: 7027Background: The ubiquitin ligase MDM2 inhibits the tumor suppressor p53. In preclinical AML models, MDM2 inhibitors have antitumor activity as monotherapy that is synergistic when combined with...
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Keywords:
study mdm2;
results phase;
dose escalation;
phase study ... See more keywords
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Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.7523
Abstract: 7523Background: Bendamustine (B) + rituximab (R; BR) is a commonly used 1L treatment for CLL. The CLL10 study reported an ORR of 96% and CR of 31% with BR. Obinutuzumab (GA101; G) is a glycoenginee...
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Keywords:
cll;
results phase;
multicenter study;
study ... See more keywords
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Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.4_suppl.345
Abstract: 345Background: GVAX is composed of irradiated, allogeneic pancreatic cancer cells modified to express GM-CSF and induce broad tumor antigen responses. Low-dose cyclophosphamide (CY) is administered with GVAX to inhibit regulatory T cells. CRS-207 is live,…
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Keywords:
chemotherapy;
results phase;
crs 207;
study ... See more keywords
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Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.5054
Abstract: 5054 Background: Preclinical models have shown that autophagy is a cell survival mechanism to overcome treatment-induced stress and facilitate progression and resistance in CRPC. Metformin (met) demonstrates autophagy inhibition and resensitizes CRPC tumors to enzalutamide…
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Keywords:
study enzalutamide;
crpc;
treatment;
results phase ... See more keywords
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Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.9557
Abstract: 9557 Background: There is growing evidence to suggest synergism between stereotactic ablative radiotherapy (SABR) and immunotherapy (IO) against metastatic melanoma. The optimal timing and dosing of SABR for this purpose has not been established. Here,…
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Keywords:
clinical trial;
pfs;
results phase;
trial ... See more keywords