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   Articles with "ret" as a keyword



Dual targeting of RET and SRC synergizes in RET fusion-positive cancer cells.

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recommendations! Published in 2025 at "Molecular oncology"

DOI: 10.1002/1878-0261.70155

Abstract: Rearranged during transfection (RET) fusions drive subsets of non-small cell lung cancer (NSCLC) and papillary thyroid carcinoma (PTC). Despite new selective RET tyrosine kinase inhibitors (TKIs), resistance usually occurs and is often driven by RET-independent… read more here.

Keywords: ret src; cancer; ret; ret fusion ... See more keywords
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Identification of a novel variant of the RET proto-oncogene in a novel family with Hirschsprung’s disease

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recommendations! Published in 2017 at "Pediatric Surgery International"

DOI: 10.1007/s00383-017-4134-z

Abstract: AbstractPurposeHirschsprung’s disease (HSCR) is a congenital disorder of the enteric nervous system characterized by the absence of ganglion cells in the Auerbach’s and Meissner’s plexuses. Although about 7% of cases are hereditary, the causal mutations… read more here.

Keywords: novel family; novel variant; disease; family ... See more keywords
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KIF5B-RET Oncoprotein Signals through a Multi-kinase Signaling Hub.

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recommendations! Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2017.08.037

Abstract: Gene fusions are increasingly recognized as important cancer drivers. The KIF5B-RET gene has been identified as a primary driver in a subset of lung adenocarcinomas. Targeting human KIF5B-RET to epithelia in Drosophila directed multiple aspects… read more here.

Keywords: kif5b ret; ret oncoprotein; signaling hub; oncoprotein signals ... See more keywords
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Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors.

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recommendations! Published in 2018 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2018.02.080

Abstract: It is now known that "gain of function" mutations of RET (REarranged during Transfection) kinase are specific and key oncogenic events in the onset of thyroid gland cancers such as the Medullary Thyroid Carcinoma (MTC).… read more here.

Keywords: medullary thyroid; challenging clinically; clinically unresponsive; ret inhibitors ... See more keywords
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Rethinking treatment for RET-altered lung and thyroid cancers: selpercatinib approval by the EMA

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recommendations! Published in 2021 at "ESMO Open"

DOI: 10.1016/j.esmoop.2020.100041

Abstract: On 10 December 2020 the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommended granting a conditional marketing authorisation for selpercatinib (Retevmo) for the treatment of cancers that display… read more here.

Keywords: rethinking treatment; ret; treatment ret; thyroid ... See more keywords
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Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology

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recommendations! Published in 2020 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.9b01336

Abstract: RET receptor tyrosine kinase is a driver oncogene in human cancer. We recently identified the clinical drug candidate Pz-1, which targets RET and VEGFR2. A key in vivo metabolite of Pz-1 is its less active… read more here.

Keywords: discovery npa101; ret vegfr2; npa101 second; bioisosteric discovery ... See more keywords

Reticulocyte Hemoglobin Equivalent (Ret-He) Combined with Red Blood Cell Distribution Width Has a Differentially Diagnostic Value for Thalassemias

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recommendations! Published in 2019 at "Hemoglobin"

DOI: 10.1080/03630269.2019.1655440

Abstract: Abstract As a type of congenital microcytic hypochromic anemia, thalassemia trait is often confused with other conditions, such as congenital sideroblastic anemia (CSA) and iron deficiency anemia, before a specific work-up is performed. However, these… read more here.

Keywords: anemia; thalassemia; value; thalassemia trait ... See more keywords

An updated patent review of rearranged during transfection (RET) kinase inhibitors (2016–present)

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recommendations! Published in 2022 at "Expert Opinion on Therapeutic Patents"

DOI: 10.1080/13543776.2022.2132851

Abstract: ABSTRACT Introduction Rearranged during transfection (RET) is a transmembrane receptor tyrosine kinase. Aberrations in RET signaling due to mutations, gene fusions, or overexpression can lead to carcinomas. Six inhibitors have been approved for the treatment… read more here.

Keywords: kinase; ret inhibitors; ret; rearranged transfection ... See more keywords

Durable response to low-dose pralsetinib in a renal insufficient patient with NSCLC harboring concurrent CCDC6-RET, LINCO1264-RET, and SEMA5A-RET fusions: A case report

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recommendations! Published in 2022 at "Medicine"

DOI: 10.1097/md.0000000000031480

Abstract: Introduction: RET-rearranged fusions have been considered as oncogenic drivers in 1% to 2% of non-small cell lung cancers (NSCLC). ARROW study has demonstrated a new selective RET tyrosine kinase inhibitors (TKIs) shows remarkable and durable… read more here.

Keywords: ccdc6; ret; patient; case ... See more keywords

Reticulon-dependent ER-phagy mediates adaptation to heat stress in C. elegans

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recommendations! Published in 2024 at "Current Biology"

DOI: 10.1101/2024.07.26.605287

Abstract: The selective degradation of ER by autophagy, named ER-phagy, promotes the recovery of ER homeostasis after a stress. Depending on the ER stress, different types of ER-phagy involve various selective autophagy receptors. In this study,… read more here.

Keywords: heat stress; stress; ret; dependent phagy ... See more keywords

MAB21L4 deficiency drives squamous cell carcinoma via activation of RET.

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recommendations! Published in 2022 at "Cancer research"

DOI: 10.1158/0008-5472.can-22-0047

Abstract: Epithelial squamous cell carcinomas (SCC) most commonly originate in the skin, where they display disruptions in the normally tightly regulated homeostatic balance between keratinocyte proliferation and terminal differentiation. We performed a transcriptome-wide screen for genes… read more here.

Keywords: scc; squamous cell; ret; differentiation ... See more keywords