Progresses Toward Precision Medicine in RET-altered Solid Tumors
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DOI: 10.1158/1078-0432.ccr-20-1587
Abstract: RET (rearranged during transfection) gene encodes a receptor tyrosine kinase essential for many physiologic functions, but RET aberrations are involved in many pathologies. While RET loss-of-function mutations are associated with congenital disorders like Hirschsprung disease… read more here.
Keywords: toward precision; medicine; precision medicine; ret ... See more keywords
Efficacy and safety of selpercatinib in Chinese patients with advanced RET-altered thyroid cancers: results from the phase II LIBRETTO-321 study
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DOI: 10.1177/17588359221119318
Abstract: Background: Selpercatinib, a highly selective and potent REarranged during Transfection (RET) kinase inhibitor, is effective in advanced RET-altered thyroid cancer (TC). However, the efficacy and safety in Chinese patients are unknown. Patients and methods: In… read more here.
Keywords: safety; altered thyroid; patients advanced; ret altered ... See more keywords
Precious Gene: The Application of RET-Altered Inhibitors
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DOI: 10.3390/molecules27248839
Abstract: The well-known proto-oncogene rearrangement during transfection (RET), also known as ret proto-oncogene Homo sapiens (human), is a rare gene that is involved in the physiological development of some organ systems and can activate various cancers,… read more here.
Keywords: ret; precious gene; gene application; ret altered ... See more keywords