Retroposed copies of RET gene: a somatically acquired event in medullary thyroid carcinoma
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DOI: 10.1186/s12920-019-0552-1
Abstract: BackgroundDifferent pathogenic germline mutations in the RET oncogene are identified in MEN 2, a hereditary syndrome characterized by medullary thyroid carcinoma (MTC) and other endocrine tumors. Although genetic predisposition is recognized, not all RET mutation… read more here.
Keywords: medullary thyroid; thyroid; mtc; ret gene ... See more keywords
CRISPR/Cas9 RET Gene Knockout in Medullary Thyroid Carcinoma Cell-lines: Optimization and Validation
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DOI: 10.18502/ijph.v51i5.9424
Abstract: Background: Medullary Thyroid Cancer (MTC) is a very aggressive type of thyroid carcinoma. Mutation in RET proto-oncogene is demonstrated in MTC development. We aimed to knock-out of RET-oncogene using CRISPR/Cas9 genome editing method in MTC… read more here.
Keywords: cell lines; crispr cas9; gene; ret gene ... See more keywords
RET Proto-Oncogene—Not Such an Obvious Starting Point in Cancer Therapy
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DOI: 10.3390/cancers14215298
Abstract: Simple Summary Rearranged during transfection (RET) is a transmembrane receptor tyrosine kinase that shows targetable mutations and gene fusions in a few types of cancers. Multiple kinase inhibitors, which target RET kinase, show little efficiency… read more here.
Keywords: ret specific; specific inhibitors; kinase; ret ... See more keywords
Adefovir Dipivoxil as a Therapeutic Candidate for Medullary Thyroid Carcinoma: Targeting RET and STAT3 Proto-Oncogenes
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DOI: 10.3390/cancers15072163
Abstract: Simple Summary In this study, we employed a cell-based assay with a luciferase gene controlled by the RET promoter to identify small molecules that inhibit the transcription of the RET gene. The RET gene plays… read more here.
Keywords: cell; thyroid carcinoma; medullary thyroid; ret gene ... See more keywords