Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aau4202
Abstract: We report the first subnanometer resolution structure of the RET extracellular domain in complex with a ligand and co-receptor. Signaling through the receptor tyrosine kinase RET is essential during normal development. Both gain- and loss-of-function… read more here.
Keywords: structure; rich domain; cysteine rich; ret signaling ... See more keywords
A New Transgenic Tool to Study the Ret Signaling Pathway in the Enteric Nervous System
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415667
Abstract: The receptor tyrosine kinase Ret plays a critical role in regulating enteric nervous system (ENS) development. Ret is important for proliferation, migration, and survival of enteric progenitor cells (EPCs). Ret also promotes neuronal fate, but… read more here.
Keywords: system; signaling pathway; ret signaling; enteric nervous ... See more keywords