Expression and purification of the extracellular domain of wild-type humanRET and the dimeric oncogenic mutant C634R.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.290
Abstract: The receptor tyrosine kinase RET is essential in a variety of cellular processes. RET gain-of-function is strongly associated with several cancers, notably multiple endocrine neoplasia type 2A (MEN 2A), while RET loss-of-function causes Hirschsprung's disease… read more here.
Keywords: dimeric oncogenic; extracellular domain; retecd; expression ... See more keywords