ZFC3H1 and U1-70K promote the nuclear retention of mRNAs with 5′ splice site motifs within nuclear speckles
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DOI: 10.1261/rna.079104.122
Abstract: Quality control of mRNA represents an important regulatory mechanism for gene expression in eukaryotes. One component of this quality control is the nuclear retention and decay of misprocessed RNAs. Previously, we demonstrated that mature mRNAs… read more here.
Keywords: retention; nuclear retention; nuclear speckles; retention mrnas ... See more keywords
Nuclear Retention of mRNAs Through Paraspeckle Protein Binding to a Sequence Determinant in 3′UTR
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DOI: 10.3390/ijms26136488
Abstract: Paraspeckles are nuclear membraneless structures composed of a long non-coding RNA, Nuclear-Enriched-Abundant-Transcript-1, and RNA-binding proteins, which associate with numerous mRNAs. It is therefore believed that their cellular function is to sequester in the nucleus their… read more here.
Keywords: retention mrnas; determinant; nuclear retention; sequence ... See more keywords