Efficient refolding of recombinant reteplase expressed in Escherichia coli strains using response surface methodology.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.183
Abstract: Reteplase is a deleted variant of human tissue plasminogen activator with a complex structure containing nine disulfide bonds. Reteplase is expressed as inclusion bodies in Escherichia coli and needs the additional step of refolding for… read more here.
Keywords: methodology; reteplase; escherichia coli; response surface ... See more keywords
Successful treatment of prosthetic pulmonary valve thrombosis with reteplase: a case report
Sign Up to like & getrecommendations! Published in 2018 at "International Medical Case Reports Journal"
DOI: 10.2147/imcrj.s168968
Abstract: Pulmonary prosthetic valve thrombosis is a serious and rare complication with high mortality. Using reteplase for treatment of prosthesis thrombosis is rarely reported. We report the first case in Iran of a thrombosed pulmonary valve… read more here.
Keywords: reteplase; case; pulmonary valve; valve thrombosis ... See more keywords
Improving the solubility, activity, and stability of reteplase using in silico design of new variants
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DOI: 10.4103/1735-5362.263560
Abstract: Reteplase (recombinant plasminogen activator, r-PA) is a thrombolytic agent recombined from tissue-type plasminogen activator (t-PA), which has several prominent features such as strong thrombolytic ability and E. coli expressibility. Despite these outstanding features, it demonstrates… read more here.
Keywords: reteplase; solubility; stability; activity ... See more keywords