Activation of fibroblastic reticular cells in kidney lymph node during crescentic glomerulonephritis.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2018.08.040
Abstract: Crescentic glomerulonephritis is an inflammatory condition characterized by rapid deterioration of kidney function. Previous studies of crescentic glomerulonephritis have focused on immune activation in the kidney. However, the role of fibroblastic reticular cells, which reside… read more here.
Keywords: kidney lymph; crescentic glomerulonephritis; reticular cells; fibroblastic reticular ... See more keywords
Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09728-3
Abstract: The splenic white pulp is underpinned by poorly characterized stromal cells that demarcate distinct immune cell microenvironments. Here we establish fibroblastic reticular cell (FRC)-specific fate-mapping in mice to define their embryonic origin and differentiation trajectories.… read more here.
Keywords: white pulp; differentiation trajectories; reticular cells; differentiation ... See more keywords
Fibroblastic reticular cells of the lymphoid tissues modulate T cell activation threshold during homeostasis via hyperactive cyclooxygenase-2/prostaglandin E2 axis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03459-5
Abstract: Fibroblastic reticular cells (FRCs) in the T cell zone of lymph nodes (LNs) are pivotal for T cell survival, mobility, and peripheral tolerance. Here, we demonstrate that during homeostasis, FRCs also suppress T cell activation… read more here.
Keywords: homeostasis; reticular cells; cell activation; activation ... See more keywords
Lymph Node Fibroblastic Reticular Cells Attenuate Immune Responses Through Induction of Tolerogenic Macrophages at Early Stage of Transplantation
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DOI: 10.1097/tp.0000000000004245
Abstract: Background. Fibroblastic reticular cells (FRCs) are a type of stromal cells located in the T zone in secondary lymphoid organs. Previous studies showed that FRCs possess the potential to promote myeloid differentiation. We aim to… read more here.
Keywords: early stage; fibroblastic reticular; reticular cells; transplantation ... See more keywords
Quantitative single molecule analysis of podoplanin clustering in fibroblastic reticular cells uncovers CD44 function
Sign Up to like & getrecommendations! Published in 2023 at "Open Biology"
DOI: 10.1098/rsob.220377
Abstract: Upon initial immune challenge, dendritic cells (DCs) migrate to lymph nodes and interact with fibroblastic reticular cells (FRCs) via C-type lectin-like receptor 2 (CLEC-2). CLEC-2 binds to the membrane glycoprotein podoplanin (PDPN) on FRCs, inhibiting… read more here.
Keywords: single molecule; reticular cells; fibroblastic reticular; quantitative single ... See more keywords
Differentiation and activation of fibroblastic reticular cells
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DOI: 10.1111/imr.12981
Abstract: Secondary lymphoid organs (SLO) are underpinned by fibroblastic reticular cells (FRC) that form dedicated microenvironmental niches to secure induction and regulation of innate and adaptive immunity. Distinct FRC subsets are strategically positioned in SLOs to… read more here.
Keywords: reticular cells; fibroblastic reticular; cell; differentiation activation ... See more keywords
Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.154250
Abstract: Acute graft versus host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT) inflicted by alloreactive T cells primed in secondary lymphoid organs (SLOs) and subsequent damage to aGvHD target tissues. In… read more here.
Keywords: cell; reticular cells; fibroblastic reticular; cd4 ... See more keywords