The odd one out: Arabidopsis reticulon 20 does not bend ER membranes but has a role in lipid regulation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20840-0
Abstract: Reticulons are integral ER membrane proteins characterised by a reticulon homology domain comprising four transmembrane domains which results in the proteins sitting in the membrane in a W-topology. Here we report on a novel subgroup… read more here.
Keywords: reticulon; role lipid; arabidopsis reticulon; lipid regulation ... See more keywords
Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc01480e
Abstract: Chemical genetics has arisen as a powerful approach for identifying novel anti-cancer agents. However, a major bottleneck of this approach is identifying the targets of lead compounds that arise from screens. Here, we coupled the… read more here.
Keywords: reticulon; colorectal cancer; pathogenicity; cancer ... See more keywords
Reticulon 3–dependent ER-PM contact sites control EGFR nonclathrin endocytosis
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DOI: 10.1126/science.aah6152
Abstract: ER-PM contacts in nonclathrin endocytosis The epidermal growth factor receptor (EGFR) is internalized through both clathrin-mediated endocytosis and nonclathrin endocytosis (NCE). The two pathways act in concert to sustain EGFR signaling or its long-term attenuation.… read more here.
Keywords: reticulon; nce; contact sites; endocytosis ... See more keywords