Piezo‐Electrons Induced Endoplasmic Reticulum Protein Misfolding to Enhance Immune Checkpoint Blockage Cancer Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202424874
Abstract: The endoplasmic reticulum (ER) is a crucial organelle in eukaryotic cells that regulates protein synthesis, folding, and transport, playing a vital role in maintaining protein homeostasis and functions. Tumor cells evade the immune surveillance and… read more here.
Keywords: cancer; reticulum; immune checkpoint; endoplasmic reticulum ... See more keywords
Structural basis of the conformational and functional regulation of human SERCA2b, the ubiquitous endoplasmic reticulum calcium pump
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200052
Abstract: Sarco/endoplasmic reticulum Ca2+ ATPase 2b (SERCA2b), a member of the SERCA family, is expressed ubiquitously and transports Ca2+ into the sarco/endoplasmic reticulum using the energy provided by ATP binding and hydrolysis. The crystal structure of… read more here.
Keywords: endoplasmic reticulum; functional regulation; structural basis; reticulum ... See more keywords
Establishment and evaluation of targeted molecular screening model for the ryanodine receptor or sarco/endoplasmic reticulum calcium ATPase.
Sign Up to like & getrecommendations! Published in 2024 at "Pest management science"
DOI: 10.1002/ps.8040
Abstract: BACKGROUD Endoplasmic reticulum/sarcoplasmic reticulum (ER/SR) is crucial for maintaining intracellular calcium homeostasis due to the calcium-signaling-related proteins on its membrane. While ryanodine receptors (RyR) on insect ER/SR membranes are well-known as targets for diamide insecticides,… read more here.
Keywords: molecular screening; reticulum; reticulum calcium; endoplasmic reticulum ... See more keywords
The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7539
Abstract: Various factors interfere with the endoplasmic reticulum (ER) function, which is involved in protein folding and calcium homeostasis. ER dysfunction referred to as ER stress triggers cell death by apoptosis and inflammation. Berberine (BBR) is… read more here.
Keywords: endoplasmic reticulum; stress; therapeutic effects; berberine different ... See more keywords
Thrombospondin 1 Promotes Endoplasmic Reticulum Stress and Apoptosis in HK-2 Cells by Upregulating ATF6-CHOP
Sign Up to like & getrecommendations! Published in 2022 at "Current Medical Science"
DOI: 10.1007/s11596-022-2513-8
Abstract: The goal of this study is to investigate the role and mechanism of endoplasmic reticulum stress and apoptosis regulated by thrombospondin 1 (TSP1) in human renal tubular epithelial cells (HK-2 cells). HK-2 cells were exposed… read more here.
Keywords: reticulum stress; endoplasmic reticulum; apoptosis; reticulum ... See more keywords
Role of the endoplasmic reticulum in synaptic transmission
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2022.102538
Abstract: Neurons possess a complex morphology spanning long distances and a large number of subcellular specializations such as presynaptic terminals and dendritic spines. This structural complexity is essential for maintenance of synaptic junctions and associated electrical… read more here.
Keywords: endoplasmic reticulum; neuronal endoplasmic; role endoplasmic; reticulum ... See more keywords
Crosstalk between Endoplasmic Reticulum stress and oxidative stress:Focus on Protein Disulfide Isomerase and Endoplasmic Reticulum Oxidase 1.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173749
Abstract: Cellular stress and inflammation, establishing as disease pathology, have reached great heights in the last few decades. Stress conditions such as hyperglycemia, hyperlipidemia and lipoproteins are known to disturb proteostasis resulting in the accumulation of… read more here.
Keywords: protein; endoplasmic reticulum; reticulum; reticulum oxidase ... See more keywords
GW28-e0577 Trimethylamine-N-oxide induces the osteogenic responses of human aortic valve interstitisl cells through the endoplasmic reticulum-mitochondrial stress pathways
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.07.061
Abstract: The recent studies show that the choline-derived metabolite trimethylamine N-oxide (TMAO) levels are associated with the development of cardiovascular diseases. TMAO causes cell inflammation and endoplasmic reticulum stress. Inflammatory responses and endoplasmic reticulum stress are involved… read more here.
Keywords: endoplasmic reticulum; reticulum; trimethylamine oxide; stress ... See more keywords
Partnership in action: The endoplasmic reticulum regulates the cytoskeleton.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of plant physiology"
DOI: 10.1016/j.jplph.2021.153540
Abstract: The endoplasmic reticulum (ER) and the cytoskeleton are functionally linked in living cells. Past research has focused on how the cytoskeleton regulates ER dynamics. How the ER may contribute to cytoskeletal dynamics has been overlooked.… read more here.
Keywords: endoplasmic reticulum; reticulum; partnership action; regulates cytoskeleton ... See more keywords
ER-GCaMP6f: An Endoplasmic Reticulum-Targeted Genetic Probe to Measure Calcium Activity in Astrocytic Processes.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04321
Abstract: Ca2+ is a major second messenger involved in cellular and subcellular signaling in a wide range of cells, including astrocytes, which use calcium ions to communicate with other cells in the brain. Even though a… read more here.
Keywords: calcium signaling; reticulum targeted; microscopy; reticulum ... See more keywords
DIAPH1-MFN2 interaction decreases the endoplasmic reticulum-mitochondrial distance and promotes cardiac injury following myocardial ischemia
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45560-0
Abstract: Contact between organelles such as the mitochondria (Mito) and endoplasmic reticulum (ER) is crucial to coordinate vital cellular homeostatic processes. Here we discuss recent work showing that Mito-ER proximity is regulated by heterotypic complexes between… read more here.
Keywords: reticulum; diaph1 mfn2; endoplasmic reticulum; injury ... See more keywords