Structural basis of the conformational and functional regulation of human SERCA2b, the ubiquitous endoplasmic reticulum calcium pump
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200052
Abstract: Sarco/endoplasmic reticulum Ca2+ ATPase 2b (SERCA2b), a member of the SERCA family, is expressed ubiquitously and transports Ca2+ into the sarco/endoplasmic reticulum using the energy provided by ATP binding and hydrolysis. The crystal structure of… read more here.
Keywords: endoplasmic reticulum; functional regulation; structural basis; reticulum ... See more keywords
The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7539
Abstract: Various factors interfere with the endoplasmic reticulum (ER) function, which is involved in protein folding and calcium homeostasis. ER dysfunction referred to as ER stress triggers cell death by apoptosis and inflammation. Berberine (BBR) is… read more here.
Keywords: endoplasmic reticulum; stress; therapeutic effects; berberine different ... See more keywords
Thrombospondin 1 Promotes Endoplasmic Reticulum Stress and Apoptosis in HK-2 Cells by Upregulating ATF6-CHOP
Sign Up to like & getrecommendations! Published in 2022 at "Current Medical Science"
DOI: 10.1007/s11596-022-2513-8
Abstract: The goal of this study is to investigate the role and mechanism of endoplasmic reticulum stress and apoptosis regulated by thrombospondin 1 (TSP1) in human renal tubular epithelial cells (HK-2 cells). HK-2 cells were exposed… read more here.
Keywords: reticulum stress; endoplasmic reticulum; apoptosis; reticulum ... See more keywords
Role of the endoplasmic reticulum in synaptic transmission
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2022.102538
Abstract: Neurons possess a complex morphology spanning long distances and a large number of subcellular specializations such as presynaptic terminals and dendritic spines. This structural complexity is essential for maintenance of synaptic junctions and associated electrical… read more here.
Keywords: endoplasmic reticulum; neuronal endoplasmic; role endoplasmic; reticulum ... See more keywords
Crosstalk between Endoplasmic Reticulum stress and oxidative stress:Focus on Protein Disulfide Isomerase and Endoplasmic Reticulum Oxidase 1.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173749
Abstract: Cellular stress and inflammation, establishing as disease pathology, have reached great heights in the last few decades. Stress conditions such as hyperglycemia, hyperlipidemia and lipoproteins are known to disturb proteostasis resulting in the accumulation of… read more here.
Keywords: protein; endoplasmic reticulum; reticulum; reticulum oxidase ... See more keywords
GW28-e0577 Trimethylamine-N-oxide induces the osteogenic responses of human aortic valve interstitisl cells through the endoplasmic reticulum-mitochondrial stress pathways
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.07.061
Abstract: The recent studies show that the choline-derived metabolite trimethylamine N-oxide (TMAO) levels are associated with the development of cardiovascular diseases. TMAO causes cell inflammation and endoplasmic reticulum stress. Inflammatory responses and endoplasmic reticulum stress are involved… read more here.
Keywords: endoplasmic reticulum; reticulum; trimethylamine oxide; stress ... See more keywords
Partnership in action: The endoplasmic reticulum regulates the cytoskeleton.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of plant physiology"
DOI: 10.1016/j.jplph.2021.153540
Abstract: The endoplasmic reticulum (ER) and the cytoskeleton are functionally linked in living cells. Past research has focused on how the cytoskeleton regulates ER dynamics. How the ER may contribute to cytoskeletal dynamics has been overlooked.… read more here.
Keywords: endoplasmic reticulum; reticulum; partnership action; regulates cytoskeleton ... See more keywords
ER-GCaMP6f: An Endoplasmic Reticulum-Targeted Genetic Probe to Measure Calcium Activity in Astrocytic Processes.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04321
Abstract: Ca2+ is a major second messenger involved in cellular and subcellular signaling in a wide range of cells, including astrocytes, which use calcium ions to communicate with other cells in the brain. Even though a… read more here.
Keywords: calcium signaling; reticulum targeted; microscopy; reticulum ... See more keywords
A Bi-fluorescence complementation system to detect associations between the Endoplasmic reticulum and mitochondria
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17278-1
Abstract: Close contacts between the endoplasmic reticulum membrane and the mitochondrial outer membrane facilitate efficient transfer of lipids between the organelles and coordinate Ca2+ signalling and stress responses. Changes to this coupling is associated with a… read more here.
Keywords: endoplasmic reticulum; reticulum; fluorescence complementation; complementation system ... See more keywords
A bridge from the endoplasmic reticulum to the plasma membrane comes into view
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202254119
Abstract: Every breath of life and every beat of the heart relies on the faithful translation of fast voltage signals into a dynamic influx of Ca ions that initiates the contraction of skeletal and cardiac muscle.… read more here.
Keywords: muscle; domain; heart; membrane ... See more keywords
CaMKII-dependent endoplasmic reticulum fission by whisker stimulation and during cortical spreading depolarization
Sign Up to like & getrecommendations! Published in 2018 at "Brain"
DOI: 10.1093/brain/awy036
Abstract: Cortical spreading depolarization waves, the cause underlying migraine aura, are also the markers and mechanism of pathology in the acutely injured human brain. Propagation of spreading depolarization wave uniquely depends on the interaction between presynaptic… read more here.
Keywords: reticulum fission; spreading depolarization; endoplasmic reticulum; reticulum ... See more keywords