Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.060
Abstract: Amyloid beta precursor protein (APP) is normally cleaved by α-secretase, but can also be cleaved by β-secretase (BACE1) to produce C99 fragments in the endoplasmic reticulum (ER) membrane. C99 is subsequently cleaved to amyloid β… read more here.
Keywords: degradation; endoplasmic reticulum; reticulum associated; c99 ... See more keywords
DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103086
Abstract: Summary Using antibody arrays, we found that the RNA helicase DDX3 modulates the expression of secreted signaling factors in oral squamous cell carcinoma (OSCC) cells. Ribo-seq analysis confirmed amphiregulin (AREG) as a translational target of… read more here.
Keywords: ddx3 modulates; endoplasmic reticulum; ddx3; reticulum associated ... See more keywords
Review: Endoplasmic Reticulum-Associated Degradation (ERAD)-Dependent Control of (Tri)terpenoid Metabolism in Plants.
Sign Up to like & getrecommendations! Published in 2018 at "Planta medica"
DOI: 10.1055/a-0635-8369
Abstract: Plants are sessile organisms. Therefore, they developed the capacity to quickly respond to biotic and abiotic environmental stresses, for instance by producing a broad spectrum of bioactive specialized metabolites. In this defense response, the jasmonate… read more here.
Keywords: endoplasmic reticulum; metabolism; degradation erad; reticulum associated ... See more keywords
Endoplasmic Reticulum-Associated Protein Degradation.
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a041247
Abstract: Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated degradation (ERAD). The ERAD process involves the recognition of substrates in the… read more here.
Keywords: endoplasmic reticulum; degradation erad; reticulum associated; protein degradation ... See more keywords
Endoplasmic reticulum–associated degradation regulates mitochondrial dynamics in brown adipocytes
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aay2494
Abstract: Organelle cross-talk Endoplasmic reticulum (ER)–associated degradation (ERAD) is a quality control mechanism that allows for targeted degradation of proteins in the ER. Zhou et al. found that a particular protein complex in ERAD, Sel1L-Hrd1, regulates… read more here.
Keywords: degradation; endoplasmic reticulum; erad; brown adipocytes ... See more keywords
Corrigendum: Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02838
Abstract: [This corrects the article DOI: 10.3389/fimmu.2019.01648.]. read more here.
Keywords: aminopeptidase erap2; associated aminopeptidase; endoplasmic reticulum; corrigendum endoplasmic ... See more keywords
The Heat Shock Protein 40-Type Chaperone MASH Supports the Endoplasmic Reticulum-Associated Degradation E3 Ubiquitin Ligase MAKIBISHI1 in Medicago truncatula
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.639625
Abstract: Jasmonates (JA) are oxylipin-derived phytohormones that trigger the production of specialized metabolites that often serve in defense against biotic stresses. In Medicago truncatula, a JA-induced endoplasmic reticulum-associated degradation (ERAD)-type machinery manages the production of bioactive… read more here.
Keywords: protein; endoplasmic reticulum; mash; medicago truncatula ... See more keywords
The Role of SBI2/ALG12/EBS4 in the Regulation of Endoplasmic Reticulum-Associated Degradation (ERAD) Studied by a Null Allele
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105811
Abstract: Redundancy and lethality is a long-standing problem in genetics but generating minimal and lethal phenotypes in the knockouts of the same gene by different approaches drives this problem to a new high. In Asn (N)-linked… read more here.
Keywords: endoplasmic reticulum; reticulum associated; erad; alg12 ebs4 ... See more keywords