Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-12070-3
Abstract: To endure over the organismal lifespan, neurons utilize multiple strategies to achieve protein homeostasis (proteostasis). Some homeostatic mechanisms act in a subcellular compartment-specific manner, but others exhibit trans-compartmental mechanisms of proteostasis. To identify pathways protecting… read more here.
Keywords: xbp; tau; endoplasmic reticulum; reticulum unfolded ... See more keywords
The endoplasmic reticulum unfolded protein response – homeostasis, cell death and evolution in virus infections
Sign Up to like & getrecommendations! Published in 2021 at "FEMS Microbiology Reviews"
DOI: 10.1093/femsre/fuab016
Abstract: ABSTRACT Viruses elicit cell and organismic stress, and offset homeostasis. They trigger intrinsic, innate and adaptive immune responses, which limit infection. Viruses restore homeostasis by harnessing evolutionary conserved stress responses, such as the endoplasmic reticulum… read more here.
Keywords: homeostasis; endoplasmic reticulum; reticulum unfolded; cell death ... See more keywords