Carba Analogues of Flupirtine and Retigabine with Improved Oxidation Resistance and Reduced Risk of Quinoid Metabolite Formation
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DOI: 10.1002/cmdc.202200262
Abstract: The KV7 potassium channel openers flupirtine and retigabine have been valuable options in the therapy of pain and epilepsy. However, as a result of adverse reactions, both drugs are currently no longer in therapeutic use.… read more here.
Keywords: improved oxidation; carba analogues; flupirtine retigabine; oxidation resistance ... See more keywords
The Kv7 Modulator, Retigabine, is an Efficacious Antiseizure Drug for Delayed Treatment of Organophosphate-induced Status Epilepticus
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DOI: 10.1016/j.neuroscience.2021.03.029
Abstract: Benzodiazepines are the primary treatment option for organophosphate (OP)-induced status epilepticus (SE), but these antiseizure drugs (ASDs) lose efficacy as treatment is delayed. In the event of a mass civilian or military exposure, significant treatment… read more here.
Keywords: treatment; status epilepticus; model; organophosphate induced ... See more keywords
Molecular Insights Into Binding and Activation of the Human KCNQ2 Channel by Retigabine
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DOI: 10.3389/fmolb.2022.839249
Abstract: Voltage-gated potassium channels of the Kv7.x family are involved in a plethora of biological processes across many tissues in animals, and their misfunctioning could lead to several pathologies ranging from diseases caused by neuronal hyperexcitability,… read more here.
Keywords: binding activation; insights binding; molecular insights; activation human ... See more keywords