Intravitreal S100B Injection Triggers a Time-Dependent Microglia Response in a Pro-Inflammatory Manner in Retina and Optic Nerve
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01786-4
Abstract: S100B is a glial protein, which belongs to calcium-binding protein family. Alterations of S100B level were noted in various neurodegenerative diseases. In a new glaucoma-like animal model S100B was injected intravitreally, which led to neuronal… read more here.
Keywords: microglia response; pro inflammatory; retina optic; optic nerve ... See more keywords
Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2019.09.003
Abstract: Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retina and optic nerve. These cells can then be used to study fundamental biology as well… read more here.
Keywords: human pluripotent; optic nerve; biology; pluripotent stem ... See more keywords
Systemic hypoxia led to little retinal neuronal loss and dramatic optic nerve glial response.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.107957
Abstract: Vision loss is a devastating consequence of systemic hypoxia, but the cellular mechanisms are unclear. We investigated the impact of acute hypoxia in the retina and optic nerve. We induced systemic hypoxia (10% O2) in… read more here.
Keywords: optic nerve; systemic hypoxia; hypoxia; retina optic ... See more keywords
Ischemic injury leads to extracellular matrix alterations in retina and optic nerve
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43470
Abstract: Retinal ischemia occurs in a variety of eye diseases. Restrained blood flow induces retinal damage, which leads to progressive optic nerve degeneration and vision loss. Previous studies indicate that extracellular matrix (ECM) constituents play an… read more here.
Keywords: extracellular matrix; optic nerve; ischemia; nerve ... See more keywords
[Results of optical coherence tomography of the retina and optic nerve in keratoconus].
Sign Up to like & getrecommendations! Published in 2021 at "Vestnik oftalmologii"
DOI: 10.17116/oftalma2021137052275
Abstract: The article reviews the results of optical coherence tomography (OCT) of the retina and optic nerve in patients with keratoconus (KC). This research direction is premised by the possibility that changes in the retina and… read more here.
Keywords: optical coherence; optic nerve; results optical; coherence tomography ... See more keywords
Changes in integrins αv and α5 with Nogo-A in the rat retina after optic nerve injury.
Sign Up to like & getrecommendations! Published in 2023 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202302_31186
Abstract: OBJECTIVE The purpose of this study was to investigate whether integrin levels are associated with axon regeneration after central nervous system (CNS) injury. MATERIALS AND METHODS By using immunohistochemistry, we performed a detailed investigation… read more here.
Keywords: integrins nogo; integrin levels; optic nerve; retina optic ... See more keywords
Hamartomas of the Retina and Optic Disc
Sign Up to like & getrecommendations! Published in 2022 at "Turkish Journal of Ophthalmology"
DOI: 10.4274/tjo.galenos.2022.25979
Abstract: Hamartomas are local malformation of cells that demonstrate abnormal proliferation in the area where they are normally present. Retinal and optic disc hamartomas include astrocytic hamartoma, congenital hypertrophy of the retinal pigment epithelium (CHRPE), simple… read more here.
Keywords: retina optic; retinal optic; disc hamartomas; optic disc ... See more keywords