Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular medicine"
DOI: 10.1007/s00109-020-01974-z
Abstract: Fibulin-3 (F3) is an extracellular matrix glycoprotein found in basement membranes across the body. An autosomal dominant R345W mutation in F3 causes a macular dystrophy resembling dry age-related macular degeneration (AMD), whereas genetic removal of… read more here.
Keywords: knockout mice; mice; fibulin; retina rpe ... See more keywords
Impact of euthanasia, dissection and postmortem delay on metabolic profile in mouse retina and RPE/choroid
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2018.05.032
Abstract: ABSTRACT Metabolomics studies in the retina and retinal pigment epithelium (RPE) in animal models or postmortem donors are essential to understanding the retinal metabolism and to revealing the underlying mechanisms of retinal degenerative diseases. We… read more here.
Keywords: retina rpe; rpe choroid; postmortem delay; rpe ... See more keywords
Transcriptional mapping of the macaque retina and RPE-choroid reveals conserved inter-tissue transcription drivers and signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.949449
Abstract: Purpose The macula and fovea comprise a highly sensitive visual detection tissue that is susceptible to common disease processes like age-related macular degeneration (AMD). Our understanding of the molecular determinants of high acuity vision remains… read more here.
Keywords: rpe; rpe choroid; retina rpe; tissue ... See more keywords