VEGFR1 signaling in retinal angiogenesis and microinflammation
Sign Up to like & getrecommendations! Published in 2021 at "Progress in retinal and eye research"
DOI: 10.1016/j.preteyeres.2021.100954
Abstract: Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A, -B, –C, -D, and placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 and 2 (VEGFR1/2), whereas VEGF-B and PlGF only bind… read more here.
Keywords: vegf; signaling retinal; angiogenesis microinflammation; vegfr1 signaling ... See more keywords
Müller cells in pathological retinal angiogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Translational Research"
DOI: 10.1016/j.trsl.2018.12.006
Abstract: &NA; Müller cells are the major glial cells spanning the entire layer of the retina and maintaining retinal structure. Under pathological conditions, Müller cells are involved in retinal angiogenesis, a process of growing new blood… read more here.
Keywords: cells pathological; pathological retinal; retinal angiogenesis; ller cells ... See more keywords
Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13220-3
Abstract: Familial exudative vitreoretinopathy (FEVR) is a human disease characterized by defective retinal angiogenesis and associated complications that can result in vision loss. Defective Wnt/β-catenin signaling is an established cause of FEVR, whereas other molecular alterations… read more here.
Keywords: exudative vitreoretinopathy; linked kinase; integrin linked; retinal angiogenesis ... See more keywords
Genome Editing of Pik3cd Impedes Abnormal Retinal Angiogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Human gene therapy"
DOI: 10.1089/hum.2022.079
Abstract: Abnormal angiogenesis is associated with myriad human diseases including proliferative diabetic retinopathy. Signaling transduction via phosphoinositide 3-kinases (PI3Ks) plays a critical role in angiogenesis. Herein, we showed that p110δ, the catalytic subunit of PI3Kδ, was… read more here.
Keywords: abnormal retinal; retinal angiogenesis; pik3cd; expression ... See more keywords
MiR‐203a‐3p inhibits retinal angiogenesis and alleviates proliferative diabetic retinopathy in oxygen‐induced retinopathy (OIR) rat model via targeting VEGFA and HIF‐1α
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13163
Abstract: Proliferative diabetic retinopathy (PDR) is a common complication of diabetes mellitus, characterized by abnormal retinal angiogenesis. MicroRNA‐203‐3p (miR‐203‐3p) was found to be down‐regulated in a murine model of proliferative retinopathy. This study was performed to… read more here.
Keywords: vegfa hif; mir 203a; retinal angiogenesis;
Bioactive lipids and pathological retinal angiogenesis
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14507
Abstract: Angiogenesis, disruption of the retinal barrier, leukocyte‐adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis.… read more here.
Keywords: proliferative retinopathies; lipids pathological; angiogenesis; pathological retinal ... See more keywords
Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14002
Abstract: The mechanism underlying vasoproliferative retinopathies like retinopathy of prematurity (ROP) is hypoxia‐triggered neovascularisation. Nerve growth factor (NGF), a neurotrophin supporting survival and differentiation of neuronal cells may also regulate endothelial cell functions. Here we studied… read more here.
Keywords: nerve growth; pathological retinal; endothelial cell; growth factor ... See more keywords
Procollagen C-proteinase enhancer 1 promotes physiologic retinal angiogenesis via regulating the process of collagen.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2022.06.03
Abstract: AIM To investigate the role of procollagen C-proteinase enhancer 1 (PCPE1) in retinal angiogenesis and relevant mechanisms. METHODS The Pcolce1-knockout (KO) mice were used to explore the effect of PCPE1 on retinal angiogenesis in vivo.… read more here.
Keywords: retinal angiogenesis; procollagen proteinase; collagen; proteinase enhancer ... See more keywords
Progress and Challenges of Anti-VEGF Agents and Their Sustained-Release Strategies for Retinal Angiogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s383101
Abstract: Abstract Currently, the treatment for ocular neovascular diseases, including diabetic macular edema (DME) and age-related macular degeneration (AMD), mainly involves repeated intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs. Although it can preserve vision,… read more here.
Keywords: vegf agents; retinal angiogenesis; anti vegf; release strategies ... See more keywords
Overexpression of Twist1 in vascular endothelial cells promotes pathological retinal angiogenesis in mice
Sign Up to like & getrecommendations! Published in 2022 at "Zoological Research"
DOI: 10.24272/j.issn.2095-8137.2021.281
Abstract: Retinal angiogenesis is a critical process for normal retinal function. However, uncontrolled angiogenesis can lead to pathological neovascularization (NV), which is closely related to most irreversible blindness-causing retinal diseases. Understanding the molecular basis behind pathological… read more here.
Keywords: retinal angiogenesis; overexpression twist1; pathological retinal; angiogenesis ... See more keywords