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   Articles with "retinal barrier" as a keyword



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Silencing Nogo-B improves the integrity of blood-retinal barrier in diabetic retinopathy via regulating Src, PI3K/Akt and ERK pathways.

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recommendations! Published in 2021 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2021.10.024

Abstract: OBJECTIVE To examine the mechanisms of Nogo-B (RTN4B) in the protection of blood-retinal barrier in experimental diabetic retinopathy. METHODS The level of Nogo-B in vitreous and plasma samples was detected with ELISA. Diabetes was induced… read more here.

Keywords: blood retinal; retinal barrier; diabetic retinopathy; silencing nogo ... See more keywords

Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.06.093

Abstract: SUMMARY Retinitis pigmentosa (RP) initiates with diminished rod photoreceptor function, causing peripheral and nighttime vision loss. However, subsequent loss of cone function and high-resolution daylight and color vision is most debilitating. Visual pigment-rich photoreceptor outer… read more here.

Keywords: blood outer; retinal barrier; outer retinal; retinitis pigmentosa ... See more keywords

C1q/TNF‐related protein‐9 attenuates retinal inflammation and protects blood–retinal barrier in db/db mice

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recommendations! Published in 2019 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2019.04.012

Abstract: ABSTRACT C1q/TNF‐related protein‐9(CTRP9) is an adipose cytokine, a closest adiponectin paralog, which has anti‐inflammatory, antioxidant, vasodilation and anti‐atherosclerosis effects. In addition, it can increase insulin sensitivity, decrease blood glucose level and inhibit the apoptosis of… read more here.

Keywords: retinal barrier; protein; blood retinal; c1q tnf ... See more keywords

Shear stress modulates inner blood retinal barrier phenotype.

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recommendations! Published in 2019 at "Experimental eye research"

DOI: 10.1016/j.exer.2019.107751

Abstract: The vascular endothelium responds to the shear stress generated by blood flow and changes function to maintain tissue homeostasis and adapt to injury in pathological conditions. Shear stress in the retinal circulation is altered in… read more here.

Keywords: retinal barrier; blood retinal; shear stress; inner blood ... See more keywords
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Transcriptomics analysis of pericytes from retinas of diabetic animals reveals novel genes and molecular pathways relevant to blood-retinal barrier alterations in diabetic retinopathy.

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recommendations! Published in 2020 at "Experimental eye research"

DOI: 10.1016/j.exer.2020.108043

Abstract: Selective pericyte loss, the histological hallmark of early diabetic retinopathy (DR), enhances the breakdown of the blood-retinal barrier (BRB) in diabetes. However, the role of pericytes on BRB alteration in diabetes and the signaling pathways… read more here.

Keywords: retinal barrier; diabetic retinopathy; blood retinal; analysis ... See more keywords

TIM2 modulates retinal iron levels and is involved in blood-retinal barrier breakdown.

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recommendations! Published in 2020 at "Experimental eye research"

DOI: 10.1016/j.exer.2020.108292

Abstract: Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in… read more here.

Keywords: retinal barrier; retinal iron; blood retinal; iron ... See more keywords
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Internal limiting membrane: The innermost retinal barrier.

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recommendations! Published in 2017 at "Medical hypotheses"

DOI: 10.1016/j.mehy.2016.11.017

Abstract: Recently, peeling of internal limiting membrane (ILM) has become one of the most common and effective surgical procedures for macular disorders. The authors discuss the adverse effects of such procedures and explore the possible functions… read more here.

Keywords: retinal barrier; internal limiting; limiting membrane; innermost retinal ... See more keywords

Effect of sitagliptin on diabetes-induced hyperpermeability of blood-retinal barrier components

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recommendations! Published in 2025 at "Eye"

DOI: 10.1038/s41433-025-03924-w

Abstract: The important role of neurodegeneration in the pathogenesis of diabetic retinal disease (DRD) and the evidence that several neuroprotective retinal factors are downregulated in diabetes have led to propose replacement treatment via eyedrops of these… read more here.

Keywords: hyperpermeability; retinal barrier; effect sitagliptin; blood retinal ... See more keywords

Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-45456-z

Abstract: Diabetic retinopathy (DR) is a microvascular disorder characterized by inner blood-retinal barrier (iBRB) breakdown and irreversible vision loss. While the symptoms of DR are known, disease mechanisms including basement membrane thickening, pericyte dropout and capillary… read more here.

Keywords: retinal barrier; inner blood; blood retinal; ibrb ... See more keywords

Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-13621-8

Abstract: Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retinopathy and other chronic retinal diseases, results in vasogenic edema and neural tissue damage, causing vision loss. Vasoinhibins are N-terminal fragments of prolactin that prevent… read more here.

Keywords: retinal barrier; blood retinal; permeability; trpv4 ... See more keywords

Single-cell transcriptomic analysis of retinal immune regulation and blood-retinal barrier function during experimental autoimmune uveitis

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-68401-y

Abstract: Uveitis is characterised by breakdown of the blood-retinal barrier (BRB), allowing infiltration of immune cells that mediate intraocular inflammation, which can lead to irreversible damage of the neuroretina and the loss of sight. Treatment of… read more here.

Keywords: retinal barrier; single cell; blood retinal; cell ... See more keywords