Retinal Cholesterol Content Is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol
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DOI: 10.1124/dmd.118.083345
Abstract: Statins, a class of cholesterol-lowering drugs, are currently being investigated for treatment of age-related macular degeneration, a retinal disease. Herein, retinal and serum concentrations of four statins (atorvastatin, simvastatin, pravastatin, and rosuvastatin) were evaluated after… read more here.
Keywords: simvastatin; cholesterol; serum; retinal cholesterol ... See more keywords
Retinal cholesterol metabolism is perturbated in response to experimental glaucoma in the rat
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DOI: 10.1371/journal.pone.0264787
Abstract: Alterations of cholesterol metabolism have been described for many neurodegenerative pathologies, such as Alzheimer’s disease in the brain and age-related macular degeneration in the retina. Recent evidence suggests that glaucoma, which is characterized by the… read more here.
Keywords: metabolism perturbated; cholesterol metabolism; rat; retinal cholesterol ... See more keywords
Characterizations of Hamster Retina as a Model for Studies of Retinal Cholesterol Homeostasis
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DOI: 10.3390/biology10101003
Abstract: Simple Summary This work represents a comprehensive evaluation of hamster retina by state-of-the-art methodologies and provides evidence that hamsters may represent a better model for studies of retinal cholesterol maintenance than mice. The latter is… read more here.
Keywords: retinal cholesterol; cholesterol homeostasis; cholesterol; hamster retina ... See more keywords