Acellularized Uvea Hydrogel as Novel Injectable Platform for Cell‐Based Delivering Treatment of Retinal Degeneration and Optimizing Retinal Organoids Inducible System
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202114
Abstract: Replenishing the retina with retinal pigment epithelial (RPE) cells derived from pluripotent stem cells (PSCs) has great promise for treating retinal degenerative diseases, but it is limited by poor cell survival and integration in vivo.… read more here.
Keywords: cell; rpe cells; uvea hydrogel; retinal degeneration ... See more keywords
Specific ablation of Hippo signalling component Yap1 in retinal progenitors and Müller cells results in late onset retinal degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30757
Abstract: Yes‐associated protein (YAP) is a major component of the Hippo pathway involved in development, growth, repair and homeostasis. Nonsense YAP1 mutations in humans result in autosomal dominant coloboma. Here, we generated a conditional knockout mouse… read more here.
Keywords: degeneration; retinal degeneration; onset retinal; hippo ... See more keywords
Testing for Known Retinal Degeneration Mutants in Mouse Strains.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8669-9_3
Abstract: Approximately 93 years ago at the zoological laboratories of Harvard University, Keeler, a medical geneticist, discovered a retina from a male albino mouse that was completely devoid of visual cells (rods). This rodless mouse was to… read more here.
Keywords: testing known; degeneration mutants; mutants mouse; retinal degeneration ... See more keywords
CRB1 related retinal degeneration with novel mutation
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Ophthalmology Case Reports"
DOI: 10.1016/j.ajoc.2020.100699
Abstract: Purpose To describe novel and previously unreported genetic mutations in the CRB1 gene in a patient with retinal dystrophy. To increase the genotype-phenotype understanding of CRB1-related retinal degenerative diseases and describe patients’ response to therapy.… read more here.
Keywords: crb1 related; related retinal; novel mutation; retinal degeneration ... See more keywords
Lipoxin A4 delays the progression of retinal degeneration via the inhibition of microglial overactivation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.137
Abstract: BACKGROUND Retinal degeneration (RD) is characterized by progressive photoreceptor degeneration, and emerging evidence has demonstrated that activated microglia-mediated inflammation exacerbates the progression of RD. Lipoxin A4 (LXA4) is an endogenous neuroprotective lipid mediator, but the… read more here.
Keywords: progression retinal; lipoxin delays; retinal degeneration; degeneration ... See more keywords
Ferrostatin-1 attenuates ferroptosis and protects the retina against light-induced retinal degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.055
Abstract: Degenerative retinal diseases, including age-related macular degeneration, are serious diseases that may lead to irreversible retinal neuron damage and permanent vision impairment. There are currently no effective treatments for these diseases due to our incomplete… read more here.
Keywords: induced retinal; light induced; ferroptosis; retinal degeneration ... See more keywords
IFN-β signaling dampens microglia reactivity but does not prevent from light-induced retinal degeneration
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2020.100866
Abstract: Chronic activation of microglia is associated with retinal degeneration, which makes them a potential therapeutic target for retinal degenerative diseases including age-related macular degeneration (AMD). Interferon-beta (IFN-β) is a potent immune regulator, commonly used for… read more here.
Keywords: ifn; reactivity; retinal degeneration; prevent ... See more keywords
Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.064
Abstract: SUMMARY Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction. Here… read more here.
Keywords: toll like; oxidative damage; retinal degeneration; degeneration ... See more keywords
Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.09.005
Abstract: Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration. In all these disorders excitotoxicity is a prominent component of… read more here.
Keywords: mglu1 metabotropic; mglu1; metabotropic glutamate; retinal degeneration ... See more keywords
Persistent remodeling and neurodegeneration in late-stage retinal degeneration
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2019.07.004
Abstract: Retinal remodeling is a progressive series of negative plasticity revisions that arise from retinal degeneration, and are seen in retinitis pigmentosa, age-related macular degeneration and other forms of retinal disease. These processes occur regardless of… read more here.
Keywords: late stage; retinal remodeling; neurodegeneration; retinal degeneration ... See more keywords
iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2016.12.008
Abstract: Summary Recent success in functional recovery by photoreceptor precursor transplantation in dysfunctional retina has led to an increased interest in using embryonic stem cell (ESC) or induced pluripotent stem cell (iPSC)-derived retinal progenitors to treat… read more here.
Keywords: stage retinal; end stage; retinal degeneration; ipsc derived ... See more keywords