Retinitis Pigmentosa and Retinal Degenerations: Deciphering Pathways and Targets for Drug Discovery and Development.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00358
Abstract: Inherited retinal diseases (IRDs) are a group of retinopathies generally caused by genetic mutations. Retinitis pigmentosa (RP) represents one of the most studied IRD, leading to intense vision loss or blindness resulting from the degeneration… read more here.
Keywords: degenerations deciphering; retinitis pigmentosa; drug; pigmentosa retinal ... See more keywords
Visualisation of peripheral retinal degenerations and anomalies with ocular imaging
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in Ophthalmology"
DOI: 10.1080/08820538.2022.2039222
Abstract: ABSTRACT Purpose Certain peripheral retinal degenerations pose a significant risk to vision and require prompt detection and management. Other historically “benign” peripheral lesions are being recognised as clinically significant due to their associations with ocular… read more here.
Keywords: degenerations anomalies; ocular imaging; peripheral lesions; visualisation peripheral ... See more keywords
Disparities in Inherited Retinal Degenerations
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in Ophthalmology"
DOI: 10.1080/08820538.2022.2152715
Abstract: ABSTRACT To review disparities in the field of inherited retinal degenerations to establish foundations for future discussions oriented toward finding possible solutions. A narrative overview of the literature. Despite collective efforts towards democratization of genetic… read more here.
Keywords: disparities inherited; retinal degenerations; inherited retinal;
Leveraging Zebrafish to Study Retinal Degenerations
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2018.00110
Abstract: Retinal degenerations are a heterogeneous group of diseases characterized by death of photoreceptors and progressive loss of vision. Retinal degenerations are a major cause of blindness in developed countries (Bourne et al., 2017; De Bode,… read more here.
Keywords: zebrafish; regeneration; study; photoreceptor regeneration ... See more keywords
The double-edged sword of inflammation in inherited retinal degenerations: Clinical and preclinical evidence for mechanistically and prognostically impactful but treatable complications
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DOI: 10.3389/fcell.2023.1177711
Abstract: We present retrospective data from our clinical research efforts of the past several years alongside a review of past and current clinical and preclinical data independently by several investigators supporting our clinical evidence for the… read more here.
Keywords: clinical preclinical; inflammation; inherited retinal; evidence ... See more keywords
Gene-agnostic approaches to treating inherited retinal degenerations
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1177838
Abstract: Most patients with inherited retinal degenerations (IRDs) have been waiting for treatments that are “just around the corner” for decades, with only a handful of seminal breakthroughs happening in recent years. Highlighting the difficulties in… read more here.
Keywords: agnostic approaches; inherited retinal; approaches treating; gene ... See more keywords