The sonic hedgehog signaling pathway is suppressed following PCB1254 exposure during retinal development
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Toxicology"
DOI: 10.1002/tox.22689
Abstract: Polychlorinated biphenyl (PCB) has been reported to have detrimental effects on retinal development. In order to explore the role of Shh signaling in retinal development after PCB1254 exposure in vivo and in vitro, zebrafish and… read more here.
Keywords: treated groups; pcb1254 treated; retinal development; development ... See more keywords
Role of mTORC1 activity during early retinal development and lamination in human-induced pluripotent stem cell‐derived retinal organoids
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-022-00837-5
Abstract: Retinal organoids derived from human-induced pluripotent stem cells (hiPSC) are powerful tools for studying retinal development as they model spatial and temporal differentiation of retinal cell types. Vertebrate retinal development involves a delicate and coordinated… read more here.
Keywords: development; retinal organoids; retinal development; role ... See more keywords
Mutant kri1l causes abnormal retinal development via cell cycle arrest and apoptosis induction
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-024-02022-2
Abstract: Damage to the ribosome or an imbalance in protein biosynthesis can lead to some human diseases, such as diabetic retinopathy (DR) and other eye diseases. Here, we reported that the kri1l gene was responsible for… read more here.
Keywords: cell cycle; kri1l; cell; retinal development ... See more keywords
Identification of a modular super-enhancer in murine retinal development
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27924-y
Abstract: Super-enhancers are expansive regions of genomic DNA comprised of multiple putative enhancers that contribute to the dynamic gene expression patterns during development. This is particularly important in neurogenesis because many essential transcription factors have complex… read more here.
Keywords: development; expression; retinal development; cell ... See more keywords
Mind Bomb-Binding Partner RanBP9 Plays a Contributory Role in Retinal Development
Sign Up to like & getrecommendations! Published in 2017 at "Molecules and Cells"
DOI: 10.14348/molcells.2017.2308
Abstract: Ran-binding protein family member, RanBP9 has been reported in various basic cellular mechanisms and neuropathological conditions including schizophrenia. Previous studies have reported that RanBP9 is highly expressed in the mammalian brain and retina; however, the… read more here.
Keywords: ranbp9; mind bomb; retinal development; role ... See more keywords
Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1106547
Abstract: Microglia are dynamic guardians of neural tissue and the resident immune cells of the central nervous system (CNS). The disease-associated microglial signature (DAM), also known as the microglial neurodegenerative phenotype (MGnD), has gained significant attention… read more here.
Keywords: myeloid masquerade; masquerade microglial; disease; retinal development ... See more keywords
Müller Glia in Retinal Development: From Specification to Circuit Integration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2021.815923
Abstract: Müller glia of the retina share many features with astroglia located throughout the brain including maintenance of homeostasis, modulation of neurotransmitter spillover, and robust response to injury. Here we present the molecular factors and signaling… read more here.
Keywords: ller glia; development specification; retinal development; development ... See more keywords