Direct repression of IGF2 is implicated in the anti-angiogenic function of microRNA-210 in human retinal endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Angiogenesis"
DOI: 10.1007/s10456-018-9597-6
Abstract: Pathological angiogenesis leads to the development of retinal vasculopathies and causes severe vision impairment. Increased understanding of the mechanisms underlying the angiogenic behavior of retinal endothelial cells helps provide new insights for developing treatment of… read more here.
Keywords: hrecs; angiogenic function; igf2; endothelial cells ... See more keywords
Tanshinone IIa protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase 1.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172419
Abstract: Advanced glycation end products (AGEs) play an important role in the onset of diabetic retinopathy. Therefore, in the current study, we investigate whether and how Tanshinone IIa (Tan IIa) from Salvia miltiorrhiza protects bovine retinal… read more here.
Keywords: mgo; tan iia; mitochondrial fission; iia ... See more keywords
Inhibition of interleukin‐6 trans‐signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2018.09.009
Abstract: ABSTRACT Vascular inflammation plays a critical role in the pathogenesis of diabetic retinopathy. Recently, Interleukin‐6 (IL‐6) trans‐signaling via soluble IL‐6 receptor (sIL‐6R) has emerged as a prominent regulator of inflammation in endothelial cells. This study… read more here.
Keywords: inflammation; trans signaling; barrier disruption; endothelial cells ... See more keywords
Exosomes derived from platelet-rich plasma mediate hyperglycemia-induced retinal endothelial injury via targeting the TLR4 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107813
Abstract: In this study, we aimed to investigate whether exosomes derived from platelet-rich plasma (PRP-Exos) can regulate hyperglycemia-induced retinal injury via targeting the TLR4 signaling pathway. We studied the effects of PRP-Exos on retinal endothelial injury… read more here.
Keywords: endothelial injury; induced retinal; prp exos; injury ... See more keywords
Type of culture medium determines properties of cultivated retinal endothelial cells: induction of substantial phenotypic conversion by standard DMEM
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e06037
Abstract: Contradictory behavior of microvascular retinal endothelial cells (REC) - a reliable in vitro model to study retinal diseases - have recently been reported which might result from cultivating the cells in standard DMEM not optimized… read more here.
Keywords: medium; conversion; standard dmem; endothelial cells ... See more keywords
Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09731-y
Abstract: Hyperhomocysteinemia (HHcy) is associated with several human visual disorders, such as diabetic retinopathy (DR) and age-related macular degeneration (AMD). Breakdown of the blood-retinal barrier (BRB) is linked to vision loss in DR and AMD. Our… read more here.
Keywords: angiogenic potential; activation oxidative; endothelial cells; retinal endothelial ... See more keywords
Sulodexide reduces glucose induced senescence in human retinal endothelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90987-w
Abstract: Chronic exposure of retinal endothelium cells to hyperglycemia is the leading cause of diabetic retinopathy. We evaluated the effect of high glucose concentration on senescence in human retinal endothelial cells (HREC) and modulation of that… read more here.
Keywords: human retinal; hrec; senescence; endothelial cells ... See more keywords
MiR-181 enhances proliferative and migratory potentials of retinal endothelial cells in diabetic retinopathy by targeting KLF6.
Sign Up to like & getrecommendations! Published in 2022 at "Current eye research"
DOI: 10.1080/02713683.2022.2039206
Abstract: PURPOSE We aimed to uncover the role of microRNA-181 (miR-181) in the disease onset of diabetic retinopathy (DR) and its underlying mechanism. METHODS MiR-181 levels in plasma and aqueous humor samples of non-proliferative diabetic retinopathy… read more here.
Keywords: mir 181; klf6; retinal endothelial; enhances proliferative ... See more keywords
Expression of Long Non-Coding RNAs in Activated Human Retinal Vascular Endothelial Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Ocular immunology and inflammation"
DOI: 10.1080/09273948.2022.2122512
Abstract: PURPOSE Retinal endothelial cell activation is a central event in non-infectious posterior uveitis. There is recent interest in long non-coding (lnc)RNA-targeted therapeutics for retinal diseases. We aimed to identify human retinal endothelial cell lncRNAs that… read more here.
Keywords: long non; endothelial cells; expression; human retinal ... See more keywords
Carnosol attenuates high glucose damage in human retinal endothelial cells through regulation of ERK/Nrf2/HO-1 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2022.2137022
Abstract: Carnosol is a natural compound with antioxidant properties. Based on this evidence, in the present study we investigated whether this compound can protect retinal vascular endothelium from hyperglycemic insult responsible for diabetic retinopathy development. We… read more here.
Keywords: damage; endothelial cells; high glucose; human retinal ... See more keywords
Inhibition of Single Routes of Intracellular Signaling is Not Sufficient to Neutralize the Biphasic Disturbance of a Retinal Endothelial Cell Barrier Induced by VEGF-A165
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000479213
Abstract: Background/Aims: Hallmark of diabetic macular edema is the enhanced permeability of retinal endothelial cells (REC) induced by vascular endothelial growth factor (VEGF-A165), which acts through activating specific receptors. To improve the predictability of inhibitors' potentials… read more here.
Keywords: barrier; vegf a165; retinal endothelial; inhibition ... See more keywords