Multimodal investigation of melanopsin retinal ganglion cells in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.51773
Abstract: OBJECTIVE In Alzheimer's disease (AD), the presence of circadian dysfunction is well-known and may occur early in the disease course. The melanopsin retinal ganglion cell (mRGC) system may play a relevant role in contributing to… read more here.
Keywords: ganglion; disease; alzheimer disease; retinal ganglion ... See more keywords
Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25272
Abstract: Obtaining a parts list of the sensory components of the retina is vital to understand the effects of light in behavior, health, and disease. Rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs) are the… read more here.
Keywords: cells retinal; retinal ganglion; neuropsin opn5; ganglion cells ... See more keywords
Retinal ganglion cells expressing CaM kinase II in human and nonhuman primates
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25292
Abstract: Immunoreactivity for calcium‐/calmodulin‐dependent protein kinase II (CaMKII) in the primate dorsal lateral geniculate nucleus (dLGN) has been attributed to geniculocortical relay neurons and has also been suggested to arise from terminals of retinal ganglion cells.… read more here.
Keywords: ganglion; kinase; ganglion cells; retinal ganglion ... See more keywords
Distribution of prototypical primary cilia markers in subtypes of retinal ganglion cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25326
Abstract: Loss of retinal ganglion cells (RGCs) underlies several forms of retinal disease including glaucomatous optic neuropathy, a leading cause of irreversible blindness. Several rare genetic disorders associated with cilia dysfunction have retinal degeneration as a… read more here.
Keywords: rgc cilia; cilia markers; ganglion cells; retinal ganglion ... See more keywords
Taurine Promotes Retinal Ganglion Cell Survival Through GABAB Receptor Activation.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-94-024-1079-2_54
Abstract: Retinal ganglion cell (RGC) degeneration occurs in numerous retinal diseases, either as a primary process like in glaucoma, or secondary to photoreceptor loss and no efficient compound targeting directly RGC neuroprotection is yet available. We… read more here.
Keywords: retinal ganglion; ganglion cell; receptor; taurine ... See more keywords
Retinal ganglion cell complex and peripapillary retinal nerve fiber layer thicknesses following carotid endarterectomy
Sign Up to like & getrecommendations! Published in 2018 at "International Ophthalmology"
DOI: 10.1007/s10792-018-0973-4
Abstract: AbstractPurpose To examine changes in retinal ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (RNFL) thicknesses by optical coherence tomography (OCT) in contralateral and ipsilatateral eyes of carotid artery stenosis (CAS) patients before… read more here.
Keywords: retinal ganglion; layer; peripapillary retinal; retinal nerve ... See more keywords
Increased Retinal Ganglion Cell Survival by Exogenous IL-2 Depends on IL-10, Dopamine D1 Receptors, and Classical IL-2/IL-2R Signaling Pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03313-1
Abstract: Interleukin-2 (IL-2) is a classical pro-inflammatory cytokine known to display neuroprotective roles in the central nervous system including the retina. In the present study, we investigate the molecular targets involved in the neurotrophic effect of… read more here.
Keywords: cell survival; retinal ganglion; rgc; dopamine receptors ... See more keywords
Synaptic or Non-synaptic? Different Intercellular Interactions with Retinal Ganglion Cells in Optic Nerve Regeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02781-y
Abstract: Axons of adult neurons in the mammalian central nervous system generally fail to regenerate by themselves, and few if any therapeutic options exist to reverse this situation. Due to a weak intrinsic potential for axon… read more here.
Keywords: non synaptic; optic nerve; intercellular interactions; retinal ganglion ... See more keywords
P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114199
Abstract: To investigate the role of P2X7 receptor to preserve retinal ganglion cells (RGCs) structure and function in a genetic mouse model (DBA/2J mouse) of age-related glaucomatous neurodegeneration. Chronic treatment with P2X7 receptor antagonist eye drops… read more here.
Keywords: glaucomatous mice; retinal ganglion; ganglion cells; receptor ... See more keywords
The S1P1 receptor‐selective agonist CYM‐5442 protects retinal ganglion cells in endothelin‐1 induced retinal ganglion cell loss
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2017.08.005
Abstract: ABSTRACT We investigated the feasibility and efficacy of using a specific sphingosine 1–phosphate (S1P1) receptor agonist, CYM‐5442, to slow or block retinal ganglion cell (RGC) loss in endothelin‐1 (ET‐1) induced RGC loss. A single intravitreal… read more here.
Keywords: retinal ganglion; cym 5442; cell; loss ... See more keywords
Aerobic exercise delays retinal ganglion cell death after optic nerve injury.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108240
Abstract: Aerobic exercise has been shown to play a crucial role in preventing neurological diseases and improving cognitive function. In the present study, we investigated the effect of treadmill training on retinal ganglion cells (RGCs) following… read more here.
Keywords: retinal ganglion; aerobic exercise; exercise; optic nerve ... See more keywords