A flibercept regulates retinal inflammation elicited by high glucose via the PlGF/ERK pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.07.021
Abstract: Diabetic retinopathy (DR) is a secondary complication of diabetes. DR can cause irreversible blindness, and its pathogenesis has been considered multifactorial. DR can progress from non-proliferative DR to proliferative DR, characterized by retinal neovascularization. The… read more here.
Keywords: aflibercept anti; retinal inflammation; plgf; flibercept regulates ... See more keywords
Inhibition of acetylcholinesterase attenuated retinal inflammation via suppressing NF-κB activation.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108003
Abstract: Elevated inflammatory cytokines contribute to the pathogenesis of various retinal diseases such as diabetic retinopathy, retinal vasculitis and retinitis. However, the underlying mechanism of retinal inflammation remains largely unknown. Recent studies demonstrated that acetylcholinesterase (ACHE)… read more here.
Keywords: ache; inhibition; expression; mice ... See more keywords
Clock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inflammation research"
DOI: 10.2147/jir.s326091
Abstract: Purpose Retinal inflammation is involved in the pathogenesis of several retinal diseases. As one of the core clock genes, Nr1d1 has been reported to suppress inflammation in many diseases. We investigated whether pharmacological activation of… read more here.
Keywords: clock gene; microglia; gene nr1d1; inflammation ... See more keywords
Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db18-0912
Abstract: We have investigated the contributing role of monosodium urate (MSU) to the pathological processes associated with the induction of diabetic retinopathy (DR). In human postmortem retinas and vitreous from donors with DR, we have found… read more here.
Keywords: diabetic retinopathy; msu; retinal inflammation; monosodium urate ... See more keywords
Regulations of Retinal Inflammation: Focusing on Müller Glia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.898652
Abstract: Retinal inflammation underlies multiple prevalent retinal diseases. While microglia are one of the most studied cell types regarding retinal inflammation, growing evidence shows that Müller glia play critical roles in the regulation of retinal inflammation.… read more here.
Keywords: ller glia; retinal diseases; inflammation; retinal inflammation ... See more keywords
Retinal Inflammation, Oxidative Stress, and Vascular Impairment Is Ablated in Diabetic Mice Receiving XMD8-92 Treatment
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.732630
Abstract: The global number of diabetics continues to rise annually. As diabetes progresses, almost all of Type I and more than half of Type II diabetics develop diabetic retinopathy. Diabetic retinopathy is a microvascular disease of… read more here.
Keywords: diabetic retinopathy; inflammation; xmd8; retinal inflammation ... See more keywords
Caffeine Protects Against Retinal Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.824885
Abstract: Caffeine, one of the most consumed central nervous system (CNS) stimulants, is an antagonist of A1 and A2A adenosine receptors. In this study, we investigated the potential protective effects of this methylxanthine in the retinal… read more here.
Keywords: inflammation; caffeine; caffeine protects; protects retinal ... See more keywords