Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2016.12.008
Abstract: Abstract Intracellular retinal iron accumulation has been implicated in the pathogenesis of age‐related macular degeneration (AMD), the leading cause of irreversible blindness among individuals over the age of 50. Ceruloplasmin/hephaestin double knockout mice (Cp/Heph DKO)… read more here.
Keywords: zip8 zip14; retinal iron; zip14; iron ... See more keywords
TIM2 modulates retinal iron levels and is involved in blood-retinal barrier breakdown.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108292
Abstract: Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in… read more here.
Keywords: retinal barrier; retinal iron; blood retinal; iron ... See more keywords