Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23880
Abstract: Glaucoma is a degenerative disease that causes irreversible loss of vision and is characterized by retinal ganglion cell (RGC) loss. Others and we have demonstrated that chronic neuroinflammation mediated by reactive microglial cells plays a… read more here.
Keywords: microglia exposed; exosomes derived; exo ehp; retinal microglia ... See more keywords
Role of aldose reductase in diabetes-induced retinal microglia activation.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.01.020
Abstract: Diabetes-induced hyperglycemia plays a key pathogenic role in degenerative retinal diseases. In diabetic hyperglycemia, aldose reductase (AR) is elevated and linked to the pathogenesis of diabetic retinopathy (DR) and cataract. Retinal microglia (RMG), the resident… read more here.
Keywords: aldose reductase; retinal microglia; role; activation ... See more keywords
Retinal Microglia: Revealing New Opportunities for Identifying Early Biomarkers of Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2025 at "Current Eye Research"
DOI: 10.1080/02713683.2025.2517300
Abstract: Abstract Purpose To explore the role of microglia in the pathomechanism of diabetic retinopathy (DR) from an inflammatory perspective. Methods: The study was conducted by searching several databases. Relevant articles were collected, summarized, and concluded.… read more here.
Keywords: retinal microglia; new opportunities; microglia revealing; revealing new ... See more keywords
Does retinal microglia respond to peripheral nervous system injury?
Sign Up to like & getrecommendations! Published in 2024 at "Acta Ophthalmologica"
DOI: 10.1111/aos.16345
Abstract: The nervous system is the principal integration and coordination centre of the organism receiving, processing and transmitting information to produce a response that regulates and maintains homeostasis. In the central nervous system (CNS), homeostasis is… read more here.
Keywords: system; nervous system; retinal microglia; cns ... See more keywords
Retinal microglia: Functions and diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13479
Abstract: Microglia, the resident immune cells in the retina and nervous system, make irreplaceable contributions to the maintenance of normal homeostasis and immune surveillance of these systems. Recently, great progress has been made in determining the… read more here.
Keywords: microglia functions; functions diseases; retinal microglia; retinal diseases ... See more keywords
Neuroinflammation, Microglia and Implications for Retinal Ganglion Cell Survival and Axon Regeneration in Traumatic Optic Neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.860070
Abstract: Traumatic optic neuropathy (TON) refers to a pathological condition caused by a direct or indirect insult to the optic nerves, which often leads to a partial or permanent vision deficit due to the massive loss… read more here.
Keywords: resident retinal; survival axon; axon regeneration; retinal microglia ... See more keywords
Isolation and Characterization of Primary Retinal Microglia From the Human Post-mortem Eyes for Future Studies of Ocular Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.786020
Abstract: Microglia, the primary resident immunocytes in the retina, continuously function as immune system supervisors in sustaining intraocular homeostasis. Microglia relate to many diseases, such as diabetic retinopathy, glaucoma, and optic nerve injury. To further investigate… read more here.
Keywords: primary retinal; human post; retinal microglia; post mortem ... See more keywords
Effects of Fucoidans on Activated Retinal Microglia
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25116018
Abstract: Sulfated marine polysaccharides, so-called fucoidans, have been shown to exhibit anti-inflammatory and immunomodulatory activities in retinal pigment epithelium (RPE). In this study, we tested the effects of different fucoidans (and of fucoidan-treated RPE cells) on… read more here.
Keywords: retinal microglia; rpe; primary microglia; secretion ... See more keywords