Deletion of Tgfβ signal in activated microglia prolongs hypoxia‐induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24218
Abstract: Retinal neovascularization (NV) is the major cause of severe visual impairment in patients with ischemic eye diseases. While it is known that retinal microglia contribute to both physiological and pathological angiogenesis, the molecular mechanisms by… read more here.
Keywords: activated microglia; igf1 expression; retinal neovascularization; tgf ... See more keywords
MicroRNA‐384‐3p inhibits retinal neovascularization through targeting hexokinase 2 in mice with diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26871
Abstract: Diabetic retinopathy (DR) presents a microvascular complication of diabetes, which may contribute to visual impairment. The treatment of DR is still controversial. Accumulating studies have reported the role of microRNAs (miRs) in DR. This study… read more here.
Keywords: diabetic retinopathy; mir 384; mice; retinal neovascularization ... See more keywords
Interferon-γ inhibits retinal neovascularization in a mouse model of ischemic retinopathy.
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cyto.2021.155542
Abstract: Interferon-γ (IFNG) is one of the key cytokines that regulates both innate and adaptive immune responses in the body. However, the role of IFNG in the regulation of vascularization, especially in the context of Vascular… read more here.
Keywords: interferon; model; vegfa; ifng ... See more keywords
Silencing of galectin‐1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen‐induced ischemic retinopathy
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2017.02.015
Abstract: Abstract Aberrant neovascularization is a consequence of inappropriate angiogenic signaling and contributes to several diseases. Although many regulators of pathogenic angiogenesis have been identified, the understanding of this process remains incomplete. Galectin‐1 (Gal‐1), as a… read more here.
Keywords: retinal hypoxia; gal; model; neovascularization ... See more keywords
Intravitreal administration of recombinant human opticin protects against hyperoxia-induced pre-retinal neovascularization
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2021.108908
Abstract: Opticin is an extracellular glycoprotein present in the vitreous. Its antiangiogenic properties offer the potential for therapeutic intervention in conditions such as proliferative diabetic retinopathy and retinopathy of prematurity. Here, we investigated the hypothesis that… read more here.
Keywords: opticin; retinal neovascularization; administration; human opticin ... See more keywords
Molecular Mediators and Regulators of Retinal Angiogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in Ophthalmology"
DOI: 10.1080/08820538.2022.2152706
Abstract: ABSTRACT Background Retinal neovascularization is the major cause of vision loss that affects both adults and young children including premature babies. It has been a major pathology in several retinal diseases like age-related macular degeneration… read more here.
Keywords: retinal diseases; pathology; retinal neovascularization; angiogenesis ... See more keywords
Vitreous Haemorrhage and Retinal Neovascularization Secondary to Peripheral Retinal Ischemia as the Presenting Sign of a Disseminated Melanoma.
Sign Up to like & getrecommendations! Published in 2023 at "Ocular immunology and inflammation"
DOI: 10.1080/09273948.2023.2198003
Abstract: PURPOSE We describe a case of vitreous haemorrhage and retinal neovascularization secondary to peripheral retinal ischemia associated with disseminated melanoma. METHODS A retrospective case report. RESULTS A 48-year-old man presented with vitreous haemorrhage in the… read more here.
Keywords: retinal neovascularization; vitreous haemorrhage; retinal ischemia; peripheral retinal ... See more keywords
MicroRNA-409-5p promotes retinal neovascularization in diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1749484
Abstract: ABSTRACT Background: Retinal neovascularization, which is characterized by the increased proliferation, migration, and tube formation of retinal microvascular endothelial cells (RMECs), contributes to the progression of diabetic retinopathy (DR). MiR-409-5p has been reported to be… read more here.
Keywords: proliferation migration; mir 409; tube formation; migration tube ... See more keywords
Case Report: Peripheral Retinal Ischemia and Retinal Neovascularization in von Willebrand Disease
Sign Up to like & getrecommendations! Published in 2021 at "Optometry and Vision Science"
DOI: 10.1097/opx.0000000000001670
Abstract: SIGNIFICANCE Although von Willebrand disease is the most common inherited bleeding disorder, there are only a few published reports of ocular complications. To our knowledge, this is the first case of peripheral retinal ischemia and… read more here.
Keywords: willebrand disease; von willebrand; retinal neovascularization; disease ... See more keywords
Comparative study of Curcumin and Lucentis on retinal neovascularization.
Sign Up to like & getrecommendations! Published in 2022 at "Ophthalmic research"
DOI: 10.1159/000527470
Abstract: Introduction To investigate the effect of Curcumin on retinal neovascularization in mice with oxygen-induced lesions. Methods 7-day-old (P7) C57/BL6J mice were randomly divided into control group, OIR group, DMSO group, 100 mg/kg, 50 mg/kg and… read more here.
Keywords: curcumin group; curcumin; group; mice ... See more keywords
Acetylcholinesterase inhibition ameliorates retinal neovascularization and glial activation in oxygen-induced retinopathy.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2020.09.04
Abstract: AIM To investigate whether inhibition of acetylcholinesterase (AChE) by donepezil ameliorate aberrant retinal neovascularization (RNV) and abnormal glial activation in oxygen-induced retinopathy (OIR). METHODS A mouse model of RNV was induced in postnatal day 7… read more here.
Keywords: oxygen; ache; glial activation; inhibition ... See more keywords