Visual impairment and retinal and brain neurodegeneration: A population‐based study
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26237
Abstract: Visual impairment and retinal neurodegeneration are intrinsically connected and both have been associated with cognitive impairment and brain atrophy, but the underlying mechanisms remain unclear. To investigate whether transneuronal degeneration is implicated, we systematically assessed… read more here.
Keywords: retinal neurodegeneration; brain; neurodegeneration; impairment retinal ... See more keywords
Retinal Neurodegeneration in Diabetes: an Emerging Concept in Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2021 at "Current Diabetes Reports"
DOI: 10.1007/s11892-021-01428-x
Abstract: Purpose of Review Diabetic retinopathy (DR), the leading cause of blindness in working-aged adults, remains clinically defined and staged by its vascular manifestations. However, early retinal neurodegeneration may precede vascular pathology, suggesting that this neuronal… read more here.
Keywords: diabetic retinopathy; diabetic retinal; neurodegeneration; concept diabetic ... See more keywords
Protective effect of Raf-1 kinase inhibitory protein on diabetic retinal neurodegeneration through P38-MAPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Current eye research"
DOI: 10.1080/02713683.2021.1944644
Abstract: PURPOSE This study aimed to investigate the effect of Raf-1 kinase inhibitory protein (RKIP) on diabetic retinal neurodegeneration in streptozotocin-treated rat model and high glucose-treated rat Müller cells. METHODS Control and streptozotocin-treated rats were intravitreally… read more here.
Keywords: p38 mapk; overexpression; rkip; diabetic retinal ... See more keywords
Recent Developments in Diabetic Retinal Neurodegeneration: A Literature Review
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Diabetes Research"
DOI: 10.1155/2020/5728674
Abstract: Neurodegeneration plays a significant role in the complex pathology of diabetic retinopathy. Evidence suggests the onset of neurodegeneration occurs early on in the disease, and so a greater understanding of the process is essential for… read more here.
Keywords: recent developments; developments diabetic; neurodegeneration; diabetic retinal ... See more keywords
Retinal neurodegeneration in euglycemic hyperinsulinemia, prediabetes, and diabetes.
Sign Up to like & getrecommendations! Published in 2022 at "Ophthalmic research"
DOI: 10.1159/000528503
Abstract: Diabetic retinopathy (DR) is a challenging public health problem mainly because of its growing prevalence and risk of blindness. In general, our current knowledge and practice have failed to prevent the onset or progression of… read more here.
Keywords: prediabetes diabetes; neurodegeneration euglycemic; retinal neurodegeneration; hyperinsulinemia prediabetes ... See more keywords
The spatial relation of diabetic retinal neurodegeneration with diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0231552
Abstract: Purpose Diabetic retinal neurodegeneration (DRN) has been demonstrated in eyes of patients with diabetes mellitus (DM), even in the absence of diabetic retinopathy (DR). However, no studies have looked at the rate of change in… read more here.
Keywords: diabetic retinopathy; layer; diabetic retinal; per quadrant ... See more keywords
Retinal neurodegeneration in metabolic syndrome: a spectral optical coherence tomography study.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2023.02.08
Abstract: AIM To evaluate the effects of metabolic syndrome (MetS) on retinal neurodegeneration by optical coherence tomography (OCT). METHODS Patients diagnosed as MetS were compared with the age and sex-matched healthy control group (CG). Waist circumference… read more here.
Keywords: retinal neurodegeneration; metabolic syndrome; coherence tomography; group ... See more keywords
Electrically-evoked responses for retinal prostheses are differentially altered depending on ganglion cell types in outer retinal neurodegeneration caused by Crb1 gene mutation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1115703
Abstract: Background Microelectronic prostheses for artificial vision stimulate neurons surviving outer retinal neurodegeneration such as retinitis pigmentosa (RP). Yet, the quality of prosthetic vision substantially varies across subjects, maybe due to different levels of retinal degeneration… read more here.
Keywords: gene mutation; retinal neurodegeneration; rd8; outer retinal ... See more keywords
Topical nerve growth factor prevents neurodegenerative and vascular stages of diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1015522
Abstract: Specific and effective preventive treatment for diabetic retinopathy (DR) is presently unavailable, mostly because the early stages of the complication have been, until recently, poorly understood. The recent demonstration that the vascular phase of DR… read more here.
Keywords: topical nerve; retinal neurodegeneration; nerve growth; neurodegeneration ... See more keywords
Wedelolactone Attenuates N-methyl-N-nitrosourea-Induced Retinal Neurodegeneration through Suppression of the AIM2/CASP11 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020311
Abstract: N-methyl-N-nitrosourea (NMU) is widely used to model oxidative stress and inflammation mediated retinal neurodegeneration. Wedelolactone (WD) is known to have antioxidant, anti-inflammatory, and neuroprotective roles. This study tested the therapeutic potential of WD in NMU-induced… read more here.
Keywords: retinal neurodegeneration; induced retinal; neurodegeneration; wedelolactone ... See more keywords
Cellular Mechanisms of Angiogenesis in Neonatal Rat Models of Retinal Neurodegeneration
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20194759
Abstract: Νeuronal and glial cells play an important role in the development of vasculature in the retina. In this study, we investigated whether re-vascularization occurs in retinal neurodegenerative injury models. To induce retinal injury, N-methyl-D-aspartic acid… read more here.
Keywords: vascularization; angiogenesis neonatal; neonatal rat; retinal neurodegeneration ... See more keywords