Comparison of DNA stability and its related genes of neurons derived from induced pluripotent stem cells and primary retinal neurons
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11837
Abstract: Maintaining DNA stability in induced pluripotent stem cells (iPSCs) and iPSCs‐derived neurons is a challenge in their clinical application. In the present study, we compared DNA stability between primary retinal neurons and differentiated neurons. We… read more here.
Keywords: derived neurons; dna stability; stem cells; retinal neurons ... See more keywords
Do Retinal Neurons Also Represent Somatosensory Inputs? On Why Neuronal Responses Are Not Sufficient to Determine What Neurons Do
Sign Up to like & getrecommendations! Published in 2023 at "Cognitive science"
DOI: 10.1111/cogs.13265
Abstract: How does neuronal activity give rise to cognitive capacities? To address this question, neuroscientists hypothesize about what neurons "represent," "encode," or "compute," and test these hypotheses empirically. This process is similar to the assessment of… read more here.
Keywords: neurons also; inputs neuronal; represent somatosensory; retinal neurons ... See more keywords
All-optical recording and stimulation of retinal neurons in vivo in retinal degeneration mice
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0194947
Abstract: Here we demonstrate the application of a method that could accelerate the development of novel therapies by allowing direct and repeatable visualization of cellular function in the living eye, to study loss of vision in… read more here.
Keywords: optical recording; retinal neurons; optics; degeneration ... See more keywords
Single-Cell Transcriptome Profiling Reveals the Suppressive Role of Retinal Neurons in Microglia Activation Under Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.680947
Abstract: Diabetic retinopathy, as one of the common complications of diabetes mellitus, is the leading cause of blindness in the working-age population worldwide. The disease is characterized by damage to retinal vasculature, which is associated with… read more here.
Keywords: diabetic retinopathy; microglia activation; retinal neurons; diabetes mellitus ... See more keywords
Critical Examination of Müller Glia-Derived in vivo Neurogenesis in the Mouse Retina
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.830382
Abstract: Müller glia (MG) are a potential source of stem cells in the mammalian retina that could replenish lost retinal neurons for vision restoration. Unlike their counterpart in zebrafish, mammalian MG are quiescent and they do… read more here.
Keywords: ller glia; derived vivo; retinal neurons; vivo neurogenesis ... See more keywords
Adult Goat Retinal Neuronal Culture: Applications in Modeling Hyperglycemia
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00983
Abstract: Culture of adult neurons of the central nervous system (CNS) can provide a unique model system to explore neurodegenerative diseases. The CNS includes neurons and glia of the brain, spinal cord and retina. Neurons in… read more here.
Keywords: adult; adult retinal; retinal neurons; adult goat ... See more keywords
αA-Crystallin Mediated Neuroprotection in the Retinal Neurons Is Independent of Protein Kinase B
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.912757
Abstract: Phosphatidylinositol 3-kinase (PI3K)/Akt signal pathway mediates pro-survival function in neurons. In the retina, PI3K/AKT/mTOR signaling pathway is related to the early pathogenesis of diabetic retinopathy. Signaling molecules in the membrane-initiated signaling pathway exhibiting neuroprotective function… read more here.
Keywords: pi3k akt; crystallin; crystallin mediated; kinase ... See more keywords
Deficiency in Retinal TGFβ Signaling Aggravates Neurodegeneration by Modulating Pro-Apoptotic and MAP Kinase Pathways
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052626
Abstract: Transforming growth factor β (TGFβ) signaling has manifold functions such as regulation of cell growth, differentiation, migration, and apoptosis. Moreover, there is increasing evidence that it also acts in a neuroprotective manner. We recently showed… read more here.
Keywords: retinal neurons; tgf; tgf signaling; photoreceptor degeneration ... See more keywords
Recent developments of neuroprotective agents for degenerative retinal disorders
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.335140
Abstract: Retinal degeneration is a debilitating ocular complication characterized by the progressive loss of photoreceptors and other retinal neurons, which are caused by a group of retinal diseases affecting various age groups, and increasingly prevalent in… read more here.
Keywords: degeneration; retinal disorders; degenerative retinal; retinal neurons ... See more keywords
Overexpressing NeuroD1 reprograms Müller cells into various types of retinal neurons
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.355818
Abstract: The onset of retinal degenerative disease is often associated with neuronal loss. Therefore, how to regenerate new neurons to restore vision is an important issue. NeuroD1 is a neural transcription factor with the ability to… read more here.
Keywords: retinal neurons; overexpressing neurod1; reprograms ller; ller cells ... See more keywords